Multidrug-Resistant Enterobacter cloacae Complex Emerging as a Global, Diversifying Threat

MK Annavajhala, A Gomez-Simmonds… - Frontiers in …, 2019 - frontiersin.org
The Enterobacter cloacae complex (ECC) includes common nosocomial pathogens capable
of producing a wide variety of infections. Broad-spectrum antibiotic resistance, including the …

Enterobacter cloacae Complex: Clinical Impact and Emerging Antibiotic Resistance

ML Mezzatesta, F Gona, S Stefani - Future microbiology, 2012 - Taylor & Francis
Species of the Enterobacter cloacae complex are widely encountered in nature, but they can
act as pathogens. The biochemical and molecular studies on E. cloacae have shown …

Carbapenem-resistant Klebsiella pneumoniae strains exhibit diversity in aminoglycoside-modifying enzymes, which exert differing effects on plazomicin and other …

R Almaghrabi, CJ Clancy, Y Doi, B Hao… - Antimicrobial agents …, 2014 - Am Soc Microbiol
We measured in vitro activity of plazomicin, a next-generation aminoglycoside, and other
aminoglycosides against 50 carbapenem-resistant Klebsiella pneumoniae strains from two …

2-Deoxystreptamine: central scaffold of aminoglycoside antibiotics

GF Busscher, FPJT Rutjes, FL Van Delft - Chemical reviews, 2005 - ACS Publications
A key structural feature of the aminoglycoside antibiotics is a 1, 3-diaminocyclohexanetriol
termed streptamine or, in cases where the 2-hydroxy function is deoxygenated as in most …

Aminoglycoside resistance rates, phenotypes, and mechanisms of Gram-negative bacteria from infected patients in upper Egypt

GF Gad, HA Mohamed, HM Ashour - PloS one, 2011 - journals.plos.org
With the re-emergence of older antibiotics as valuable choices for treatment of serious
infections, we studied the aminoglycoside resistance of Gram-negative bacteria isolated …

Global priority pathogens: virulence, antimicrobial resistance and prospective treatment options

JC M Campos, LCM Antunes, RBR Ferreira - Future microbiology, 2020 - Taylor & Francis
Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter
baumannii, Pseudomonas aeruginosa, Enterobacter spp. and Salmonella spp. are part of a …

Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era

ZP Bulman, L Chen, TJ Walsh, MJ Satlin, Y Qian… - MBio, 2017 - Am Soc Microbiol
The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the
importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated …

Resistance Status and Evolution Trends of Klebsiella pneumoniae Isolates in a University Hospital in Greece: Ineffectiveness of Carbapenems and Increasing …

IK Neonakis, G Samonis, H Messaritakis, S Baritaki… - Chemotherapy, 2010 - karger.com
Background: Due to its increased non-susceptibility rates, Klebsiella pneumoniae has
emerged as one of the most problematic pathogens. Methods: The level of resistance to 25 …

The Major Aminoglycoside-Modifying Enzyme AAC(3)-II Found in Escherichia coli Determines a Significant Disparity in Its Resistance to Gentamicin and Amikacin in …

Y Xiao, Y Hu - Microbial Drug Resistance, 2012 - liebertpub.com
The aim of this study was to investigate the prevalence of aminoglycoside-modifying
enzymes in Escherichia coli in different areas of China and to explore the relationship …

[HTML][HTML] Extended spectrum beta-lactamase production in Shigella isolates-A matter of concern

SR Varghese, A Aggarwal - 2011 - utoronto.scholaris.ca
Shigellosis is a global human health problem [1] known to cause diarrheal disease and
death in a certain proportion of affected individuals. Shigellosis is primarily a disease of …