The absorption of orally administered drug products is a complex, dynamic process, dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …
Proteins and their interactions in and out of cells must be well-orchestrated for the healthy functioning and regulation of the body. Even the slightest disharmony can cause diseases …
H Cheng, A Chawla, Y Yang, Y Li, J Zhang, HL Jang… - Drug discovery today, 2017 - Elsevier
Highlights•The most representative nanomaterials for bone drug delivery are summarized.• Nanomaterials can target bone by oral, implant, injectable, and transdermal …
S Gupta, A Jain, M Chakraborty, JK Sahni, J Ali… - Drug …, 2013 - Taylor & Francis
Advent of recombinant technology in protein synthesis has given birth to a new range of biopharmaceuticals. These therapeutic peptides and proteins are now emerging as an …
Peptides are therapeutic molecules that can treat selectively and efficiently a wide range of pathologies. However, their intrinsic properties cause their rapid degradation in the human …
The oral administration of protein therapeutics is hindered by the multitude of barriers confronted by these molecules along the gastrointestinal tract (ie, acidic environment …
K Hemmati, M Ghaemy - International Journal of Biological Macromolecules, 2016 - Elsevier
In this study, new pH/temperature responsive graft copolymers were synthesized based on natural Tragacanth Gum (TG) carbohydrate and their controlled drug release was …
The controlled revision of surface properties to alter the hydrophobic features of nanocellulose is a potential technique to obtain materials for many novel applications and to …
RJ Mrsny - Journal of controlled release, 2012 - Elsevier
The oral delivery of drugs is considered by decision-makers in the pharmaceutical industry to be the most appealing route of administration. This belief has led to the identification of …