Sarcopenia and frailty in decompensated cirrhosis

P Tandon, AJ Montano-Loza, JC Lai, S Dasarathy… - Journal of …, 2021 - Elsevier
In patients with decompensated cirrhosis, sarcopenia and frailty are prevalent. Although
several definitions exist for these terms, in the field of hepatology, sarcopenia has commonly …

EASL Clinical Practice Guidelines on nutrition in chronic liver disease

M Merli, A Berzigotti, S Zelber-Sagi, S Dasarathy… - Journal of …, 2019 - Elsevier
A frequent complication in liver cirrhosis is malnutrition, which is associated with the
progression of liver failure, and with a higher rate of complications including infections …

Sarcopenia in cirrhosis: from pathogenesis to interventions

M Ebadi, RA Bhanji, VC Mazurak… - Journal of …, 2019 - Springer
Sarcopenia (severe muscle depletion) is a prevalent muscle abnormality in patients with
cirrhosis that confers poor prognosis both pre-and post-liver transplantation. The …

Sarcopenia from mechanism to diagnosis and treatment in liver disease

S Dasarathy, M Merli - Journal of hepatology, 2016 - Elsevier
Sarcopenia or loss of skeletal muscle mass is the major component of malnutrition and is a
frequent complication in cirrhosis that adversely affects clinical outcomes. These include …

Sarcopenic obesity and myosteatosis are associated with higher mortality in patients with cirrhosis

AJ Montano‐Loza, P Angulo… - Journal of cachexia …, 2016 - Wiley Online Library
Background and aims Obesity is frequently associated with cirrhosis, and cirrhotic patients
may develop simultaneous loss of skeletal muscle and gain of adipose tissue, culminating in …

malnutrition/sarcopenia and frailty in patients with cirrhosis

C Bunchorntavakul, KR Reddy - Alimentary pharmacology & …, 2020 - Wiley Online Library
Background Malnutrition/sarcopenia and frailty are common in patients with cirrhosis and
are associated with poor outcomes. Aim To provide an overview of data on the importance …

[HTML][HTML] Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome

M Sandri - The international journal of biochemistry & cell biology, 2013 - Elsevier
Skeletal muscle adapts its mass as consequence of physical activity, metabolism and
hormones. Catabolic conditions or inactivity induce signaling pathways that regulate the …

[PDF][PDF] Severe muscle depletion predicts postoperative length of stay but is not associated with survival after liver transplantation

AJ Montano‐Loza, J Meza‐Junco… - Liver …, 2014 - Wiley Online Library
Muscle depletion or sarcopenia is associated with increased mortality in patients with
cirrhosis; how it affects mortality after liver transplantation requires further study. In this study …

Ammonia toxicity: from head to toe?

S Dasarathy, RP Mookerjee, V Rackayova… - Metabolic brain …, 2017 - Springer
Ammonia is diffused and transported across all plasma membranes. This entails that
hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that …

[PDF][PDF] Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis

A Kumar, G Davuluri, RN Silva, MPKJ Engelen… - …, 2017 - Wiley Online Library
Sarcopenia or skeletal muscle loss is a frequent, potentially reversible complication in
cirrhosis that adversely affects clinical outcomes. Hyperammonemia is a consistent …