[HTML][HTML] Optimizing CRISPR/Cas9 precision: Mitigating off-target effects for safe integration with photodynamic and stem cell therapies in cancer treatment

JPJ Merlin, H Abrahamse - Biomedicine & Pharmacotherapy, 2024 - Elsevier
CRISPR/Cas9 precision genome editing has revolutionized cancer treatment by introducing
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …

The importance of kidney calcium handling in the homeostasis of extracellular fluid calcium

C Prot-Bertoye, L Lievre, P Houillier - Pflügers Archiv-European Journal of …, 2022 - Springer
Extracellular fluid calcium concentration must be maintained within a narrow range in order
to sustain many biological functions, encompassing muscle contraction, blood coagulation …

Ultrasmall and highly biocompatible carbon dots derived from natural plant with amelioration against acute kidney injury

X Wang, T Wu, Y Yang, L Zhou, S Wang, J Liu… - Journal of …, 2023 - Springer
Background Acute kidney injury (AKI) refers to a tricky clinical disease, known by its high
morbidity and mortality, with no real specific medicine for AKI. The carbonization product …

[HTML][HTML] Combining Photodynamic Therapy and Targeted Drug Delivery Systems: Enhancing Mitochondrial Toxicity for Improved Cancer Outcomes

JPJ Merlin, A Crous, H Abrahamse - International journal of molecular …, 2024 - mdpi.com
Cancer treatment continues to be a substantial problem due to tumor complexities and
persistence, demanding novel therapeutic techniques. This review investigates the …

Nano‐phototherapy: Favorable prospects for cancer treatment

JPJ Merlin, A Crous… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Nanotechnology‐based phototherapies have drawn interest in the fight against cancer
because of its noninvasiveness, high flexibility, and precision in terms of cancer targeting …

Targeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease

X Chen, W Dai, H Li, Z Yan, Z Liu, L He - Drug Delivery, 2023 - Taylor & Francis
Diabetic kidney disease (DKD) is the main complication in diabetes mellitus (DM) and the
main cause of end-stage kidney disease worldwide. However, sodium glucose cotransporter …

Advancing Photodynamic Therapy with Nano-Conjugated Hypocrellin: Mechanisms and Clinical Applications

SS Rajan, R Chandran… - International Journal of …, 2024 - Taylor & Francis
Hypocrellin-based photodynamic therapy (PDT) is developing as a viable cancer
therapeutic option, especially when enhanced by nanoconjugation. This review investigates …

Emerging drug delivery systems with traditional routes–A roadmap to chronic inflammatory diseases

K Min, A Sahu, SH Jeon, G Tae - Advanced Drug Delivery Reviews, 2023 - Elsevier
Inflammation is prevalent and inevitable in daily life but can generally be accommodated by
the immune systems. However, incapable self-healing and persistent inflammation can …

Nano-technological approaches for targeting kidney diseases with focus on diabetic nephropathy: recent progress, and future perspectives

B Lin, YY Ma, JW Wang - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. With
the rising prevalence of diabetes, the occurrence of DN is likely to hit pandemic proportions …

[HTML][HTML] Titanium-nanostructured and PEGylated Doxorubicin diminish chemotherapeutic resistance in 3-methylcholanthrene renal epithelial cell carcinoma via KRAS …

MO Kadry, RM Abdel-Megeed - Gene Expression, 2023 - xiahepublishing.com
Methods In-vivo models were exposed to CA at a dose of 50 mg/kg body weight and left for 3
months till the incidence of chronic kidney disease, followed by one month of treatment with …