Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a large variety of
malformations that arise from defective kidney or urinary tract development and frequently …

Wolffian duct (WD) maintenance and differentiation is predominantly driven by the androgen
action, which is mediated by the androgen receptor (AR). It is well established that the …

The GATA family of transcription factors consists of six proteins (GATA1-6) that control a
variety of physiological and pathological processes. In particular, GATA2 and GATA3 are …

The patterned array of basal, intermediate and superficial cells in the urothelium of the
mature ureter arises from uncommitted epithelial progenitors of the distal ureteric bud …

Smooth muscle cells (SMCs) are a crucial component of the mesenchymal wall of the ureter,
as they account for the efficient removal of the urine from the renal pelvis to the bladder by …

The mammalian kidney and lower urinary tract maintains and regulates water balance, acid–
base homeostasis, electrolyte equilibrium, and waste excretion. The performance of these …

The coordinated development of the mesenchymal and epithelial progenitors of the murine
ureter depends on a complex interplay of diverse signaling activities. We have recently …

The contractile phenotype of smooth muscle cells (SMCs) is transcriptionally controlled by a
complex of the DNA-binding protein SRF and the transcriptional co-activator MYOCD. The …

Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause
of end-stage kidney disease in children. While the genetic aberrations underlying CAKUT …

The kidney presents in the highest degree the phenomenon of sensibility; the power of
reacting to various stimuli in a direction which is appropriate for the survival of the organism; …