Significance: Autophagy and apoptosis are two important cellular mechanisms behind brain
injuries, which are severe clinical situations with increasing incidences worldwide. To …

Proliferation and migration of fibroblasts, keratinocytes, and endothelial cells are key events
in the physiological process of wound healing. This process includes different but …

Obesity is associated with chronic inflammation in the central nervous system (CNS), and
neuroinflammation has been shown to have detrimental effects on mood and cognition. The …

Intermittent hypoxia is the best predictor of developing cognitive decline and Alzheimer's
disease progression in patients with obstructive sleep apnea. The nucleotide-binding …

Aims Traumatic brain injury (TBI) constitutes a serious public health concern. Although TBI
targets the brain, it can exert several systemic effects which can worsen the complications …

Hypoxic-ischemic brain injury poses a significant threat to the neural niche within the central
nervous system. In response to this pathological process, microglia, as innate immune cells …

Background: Microglia are resident immune cells of the central nervous system that sense
environmental changes and maintain central nervous system homeostasis. Dysfunctional …

Traumatic injury to the brain and spinal cord (neurotrauma) is a common event across
populations and often causes profound and irreversible disability. Pathophysiological …

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three
distinct neurological disorders that share common pathophysiological mechanisms involving …

Traumatic brain injury is a leading cause of chronic neurologic disability and a risk factor for
development of neurodegenerative disease. However, little is known regarding the …