Glioblastomas (GBMs) are tumors that have a high ability to migrate, invade and proliferate
in the healthy tissue, what greatly impairs their treatment. These characteristics are …

Background: Flavonoids are polyphenolic compounds found to be present in nature and
abundant in flowers and fruits. Flavonoidal class phytochemicals have gained interest in the …

Quercetin (Q) is a bioflavonoid with biological potential; however, poor solubility in water,
extensive enzymatic metabolism and a reduced bioavailability limit its biopharmacological …

The flavonoid apigenin, extracted from the Brazilian plant Croton betulaster Müll. has
demonstrated the ability to inhibit proliferation, induce differentiation, and modify the …

This study aimed to investigate the antitumor and immunomodulatory properties of the
flavonoid apigenin (5, 7, 4′-trihydroxyflavone), which was extracted from Croton betulaster …

The genus Croton, belonging to the Euphorbiaceae family, is a plant with shrubby
characteristics, with the ability to regrow in times of rain, develops wildly, especially in …

Three new polyprenylated benzophenone derivatives (1–3) were identified in the hexane
extract of Clusia burle-marxii trunks, through the isolation and structural elucidation of their …

Glioma is an aggressive type of brain malignancy responsible for significant morbidity and
mortality. In the current scenario, epidermal growth factor receptor (EGFR) kinases targeted …

Background: Plant-derived products have been used in medicine as a source of bioactive
molecules, mainly due to their medicinal importance and therapeutic potential. Nowadays …

Purpose: Flavonoids are a group of secondary metabolites of the polyphenols class present
in several plant species. Among them, the biflavonoid agathisflavone is of interest since it …