The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …

Abstract Loss of calcium (Ca2+) homeostasis contributes through different mechanisms to
cell death occurring during the first minutes of reperfusion. One of them is an unregulated …

Background Mitochondrial fusion protein mutations are a cause of inherited neuropathies
such as Charcot–Marie–Tooth disease and dominant optic atrophy. Previously we reported …

In myocytes, small heat shock proteins (sHSPs) are preferentially translocated under stress
to the sarcomeres. The functional implications of this translocation are poorly understood …

Enhanced reactive oxygen species (ROS) at the beginning of reperfusion activated signal
transducer and activator of transcription 3 (STAT3) in intermittent hypobaric hypoxia (IHH) …

Pretreatment of berbamine protects the heart from ischemia/reperfusion (I/R) injury. However
it is unknown whether it has cardioprotection when given at the onset of reperfusion …

Small heat shock proteins (sHsps) play an important role in the maintenance of proteome
stability and, particularly, in stabilization of the cytoskeleton and cell contractile apparatus …

Abstract Uncoupling protein 2 (UCP2), located in the mitochondrial inner membrane, is a
predominant isoform of UCP that expressed in the heart and other tissues of human and …

Ischemia-Reperfusion (I/R) injury causes ROS overproduction, creating oxidative stress, and
can trigger myocyte death, resulting in heart failure. Tyrosol is an antioxidant abounded in …

Both calpain activation and endoplasmic reticulum (ER) stress are implicated in ischemic
heart injury. However, the role of calpain in ER stress remains largely elusive. This study …