The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in
1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered …

Under hypoxia, tumor cells produce a secretion that modulates their microenvironment to
facilitate tumor angiogenesis and metastasis. Here, we observed that hypoxic or …

How are biological structures maintained in a cellular environment that constantly threatens
protein integrity? Here we elucidate proteostasis mechanisms affecting the Z disk, a protein …

Loss of ER Ca 2+ homeostasis triggers endoplasmic reticulum (ER) stress and drives ER-
PM contact sites formation in order to refill ER-luminal Ca 2+. Recent studies suggest that …

From the extracellular matrix to the cytoskeleton, a network of molecular links connects cells
to their environment. Molecules in this network transmit and detect mechanical forces, which …

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin
filament networks and link them to cellular membranes where they integrate cell …

Filamins are essential, evolutionarily conserved, modular, multidomain, actin-binding
proteins that organize the actin cytoskeleton and maintain extracellular matrix connections …

The actin cytoskeleton, a network of protein-polymers, is responsible for the mechanical
stability of cells. This biopolymer network is also crucial for processes that require spatial …

Filamin A (FLNa) can effect orthogonal branching of F-actin and bind many cellular
constituents. FLNa dimeric subunits have N-terminal spectrin family F-actin binding domains …