The health and function of our visual system relies on accurate gene expression. While
many genetic mutations are associated with visual impairment and blindness, we are just …

Non‐coding RNAs (ncRNAs) are key players in variety of biogenesis and biological
functions. Their aberrant expression has been implicated in disease progression. NcRNAs …

Small noncoding RNAs (ncRNAs) play a vital role in a broad range of biological processes
both in health and disease. A comprehensive quantitative reference of small ncRNA …

Background Exosomes are small membranous structures released from cells into the blood,
regulating various biological processes. However, the role of exosomes in cardiotoxicity …

The challenge of developing gene therapies for genetic forms of blindness is heightened by
the heterogeneity of these conditions. However, mechanistic commonalities indicate key …

The peripheral deafness gene Mir96 is expressed in both the cochlea and central auditory
circuits. To investigate whether it plays a role in the auditory system beyond the cochlea, we …

The retina is among the most metabolically active tissues with high-energy demands. The
peculiar distribution of mitochondria in cells of retinal layers is necessary to assure the …

Optic Atrophy 1 (OPA1) is a mitochondrially targeted GTPase that plays a pivotal role in
mitochondrial health, with mutations causing severe mitochondrial dysfunction and typically …

Epilepsy is one of the most severe neurological disorders characterized by spontaneous
recurrent seizures. Although more than two-thirds of patients can be cured with anti-epileptic …

Mutations in tubby like protein 1 gene (TULP1) are causative of early-onset recessive
inherited retinal degenerations (IRDs); similarly, the Tulp1-/-mouse is also characterized by …