Current antiviral therapies, such as pegylated interferon-α and nucleos (t) ide analogues,
effectively improve the quality of life of patients with chronic hepatitis B. However, they can …

The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils,
causing base substitutions and strand breaks. They are induced by cytokines produced …

Although base editors are widely used to install targeted point mutations, the factors that
determine base editing outcomes are not well understood. We characterized sequence …

APOBEC family cytidine deaminases have recently been implicated as powerful mutators of
cancer genomes. How APOBECs, which are ssDNA-specific enzymes, gain access to …

Human papillomaviruses (HPVs) are small DNA viruses causally associated with benign
warts and multiple cancers, including cervical and head-and-neck cancers. While the vast …

Mutational signatures defined by single base substitution (SBS) patterns in cancer have
elucidated potential mutagenic processes that contribute to malignancy. Two prevalent …

The apolipoprotein B messenger RNA-editing, enzyme-catalytic, polypeptide-like 3
(APOBEC3) family of cytidine deaminases plays an important role in the innate immune …

The APOBEC3 restriction factors are a family of deoxycytidine deaminases that are able to
suppress replication of viruses with a single-stranded DNA intermediate by inducing …

The APOBEC3 family of cytosine deaminases are part of the innate immune response to
viral infection, but also have the capacity to damage cellular DNA. Detection of mutational …

Antiviral DNA cytosine deaminases APOBEC3A and APOBEC3B are major sources of
mutations in cancer by catalyzing cytosine-to-uracil deamination. APOBEC3A preferentially …