Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike
many other mature cell types in the adult body, VSMC do not terminally differentiate but …

The initiation of atherosclerosis results from complex interactions of circulating factors and
various cell types in the vessel wall, including endothelial cells, lymphocytes, monocytes …

Blood vessels exhibit a remarkable ability to adapt throughout life that depends upon
genetic programming and well-orchestrated biochemical processes. Findings over the past …

Vascular injury and chronic arterial diseases result in exposure of VSMCs (vascular smooth
muscle cells) to increased concentrations of growth factors. The mechanisms by which …

Objective—The mechanisms responsible for maintaining the differentiated phenotype of
adult vascular smooth muscle cells (VSMCs) are incompletely understood. Reactive oxygen …

Smooth muscle is a major component of human tissues and is essential for the normal
function of a multitude of organs including the intestine, urinary tract and the vascular …

Valvular endothelial cells interact with interstitial cells in a complex hemodynamic and
mechanical environment to maintain leaflet tissue integrity. The precise roles of each cell …

910 levels, whereas PCSK9 overexpression did not cause an increase in plasma lipids but
in atherosclerotic lesion size18, 19). The Atheroma IVUS study revealed that the necrotic …

Objective—Marfan's syndrome is characterized by the formation of ascending aortic
aneurysms resulting from altered assembly of extracellular matrix microfibrils and chronic …

Adult bone marrow-derived mesenchymal stem cells (MSC) can differentiate into various cell
types of mesenchymal origin, but mechanisms regulating such cellular changes are unclear …