Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …

Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic
brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate …

Background and Purpose—The authors present an overview of the current evidence and
management recommendations for evaluation and treatment of adults with acute ischemic …

Excitotoxicity, the specific type of neurotoxicity mediated by glutamate, may be the missing
link between ischemia and neuronal death, and intervening the mechanistic steps that lead …

Ischemic stroke, a major cause of mortality in the United States, often contributes to
disruption of the blood-brain barrier (BBB). The BBB along with its supportive cells …

Background Magnesium sulfate is neuroprotective in preclinical models of stroke and has
shown signals of potential efficacy with an acceptable safety profile when delivered early …

Purpose—Our goal is to provide an overview of the current evidence about components of
the evaluation and treatment of adults with acute ischemic stroke. The intended audience is …

This article represents the update of the European Stroke Initiative Recommendations for
Stroke Management. These guidelines cover both ischaemic stroke and transient ischaemic …

Background High blood pressure is associated with poor outcome after stroke. Whether
blood pressure should be lowered early after stroke, and whether to continue or temporarily …

Despite decades of study, subarachnoid hemorrhage (SAH) continues to be a serious and
significant health problem in the United States and worldwide. The mechanisms contributing …