Challenges for the application of EGFR-targeting peptide GE11 in tumor diagnosis and treatment

T Hailing, P Yonghong, Z Yufeng, T Haitao - Journal of Controlled Release, 2022 - Elsevier
Abnormal regulation of cell signaling pathways on cell survival, proliferation and migration
contributes to the development of malignant tumors. Among them, epidermal growth factor …

Ex vivo transdermal delivery of nicotinamide mononucleotide using polyvinyl alcohol microneedles

F Sabbagh, BS Kim - Polymers, 2023 - mdpi.com
Nicotinamide mononucleotide (NMN), which has recently been spotlighted as an anti-aging
agent, is a precursor of the coenzyme nicotinamide adenine dinucleotide that plays an …

Inhaled medicines for targeting non-small cell lung cancer

AO Al Khatib, M El-Tanani, H Al-Obaidi - Pharmaceutics, 2023 - mdpi.com
Throughout the years, considerable progress has been made in methods for delivering
drugs directly to the lungs, which offers enhanced precision in targeting specific lung …

Switching indication of PEGylated lipid nanocapsules-loaded with rolapitant and deferasirox against breast cancer: Enhanced in-vitro and in-vivo cytotoxicity

MF Kabil, MY Mahmoud, AF Bakr, D Zaafar… - Life sciences, 2022 - Elsevier
Breast cancer (BC) is considered the leading cause of mortality and morbidity among adult
women worldwide, and it is associated with many genetic or hormonal factors. Despite the …

Novel long-acting brimonidine tartrate loaded-PCL/PVP nanofibers for versatile biomedical applications: fabrication, characterization and antimicrobial evaluation

SA Salim, NM Badawi, SH El-Moslamy, EA Kamoun… - RSC …, 2023 - pubs.rsc.org
The global state of antibiotic resistance highlights the necessity for new drugs that can treat
a wide range of microbial infections. Drug repurposing has several advantages, including …

Combating hematopoietic and hepatocellular abnormalities resulting from administration of cisplatin: role of liver targeted glycyrrhetinic acid nanoliposomes loaded …

RF Ahmed, M Nasr, M Abd Elbaset… - Pharmaceutical …, 2022 - Taylor & Francis
The effectiveness of cisplatin in cancer treatment renders its use vital to clinicians. However,
the accompanying side effects as cachexia, emesis and liver damage necessitate the use of …

A comprehensive review on lipid nanocarrier systems for cancer treatment: fabrication, future prospects and clinical trials

MF Kabil, OA Badary, F Bier, SA Mousa… - Journal of Liposome …, 2024 - Taylor & Francis
Over the last few decades, cancer has been considered a clinical challenge, being among
the leading causes of mortality all over the world. Although many treatment approaches …

Recent progress on polySarcosine as an alternative to PEGylation: Synthesis and biomedical applications

MF Kabil, HMES Azzazy, M Nasr - International Journal of Pharmaceutics, 2024 - Elsevier
Biotherapeutic PEGylation to prolong action of medications has gained popularity over the
last decades. Various hydrophilic natural polymers have been developed to tackle the …

Transethosomes: A Comprehensive Review of Ultra-Deformable Vesicular Systems for Enhanced Transdermal Drug Delivery

R Seenivasan, P Halagali, D Nayak… - AAPS PharmSciTech, 2025 - Springer
The transdermal route is one of the effective routes for delivering drugs. It also overcomes
many limitations associated with oral delivery. One of the limitations of this route is the drug's …

Nanoliposomal amino acids counteracting protein malnutrition induced hematopoietic and hepatic complications

RF Ahmed, M Abd Elbaset, H Farouk… - Journal of Drug Delivery …, 2023 - Elsevier
Protein malnutrition during childhood is a primary global concern, contributing to more than
50% of childhood mortality in developing countries owing to its complications on many …