Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …

Immunometabolism explores how the intracellular metabolic pathways in immune cells can
regulate their function under different micro-environmental and (patho-)-physiological …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Chimeric antigen receptor (CAR) T-cell therapy entails the genetic engineering of a patient's
T-cells to express membrane spanning fusion receptors with defined specificities for tumor …

Heme Oxygenase 1 (HMOX1) is an enzyme that catalyzes the reaction that degrades the
heme group contained in several important proteins, such as hemoglobin, myoglobin, and …

Cells have the ability to communicate with their immediate and distant neighbors through the
release of extracellular vesicles (EVs). EVs facilitate intercellular signaling through the …

Abstract Background Dendritic cells (DCs) are important mediators of innate and adaptive
immune responses, but the gene networks governing their lineage differentiation and …

Significance: The family of gasotransmitter molecules, nitric oxide (NO), carbon monoxide
(CO), and hydrogen sulfide (H2S), has emerged as an important mediator of numerous …

Lysosomal compartments undergo extensive remodeling during dendritic cell (DC)
activation to meet the dynamic functional requirements of DCs. Instead of being regarded as …

Psoriasis is a chronic autoimmune disease mediated by dysregulated immune responses in
dendritic cells (DC) and T cells. The stress-response enzyme heme oxygenase-1 (HO-1) has …