The origin, progress, and application of cell‐based cardiac regeneration therapy

D Zhuo, I Lei, W Li, L Liu, L Li, J Ni… - Journal of Cellular …, 2023 - Wiley Online Library
Cardiovascular disease (CVD) has become a severe threat to human health, with morbidity
and mortality increasing yearly and gradually becoming younger. When the disease …

Cardiac stem cells in the postnatal heart: lessons from development

C Aguilar-Sanchez, M Michael… - Stem Cells …, 2018 - Wiley Online Library
Heart development in mammals is followed by a postnatal decline in cell proliferation and
cell renewal from stem cell populations. A better understanding of the developmental …

Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health

J Heid, C Cencioni, R Ripa, M Baumgart, S Atlante… - Scientific reports, 2017 - nature.com
The short-lived turquoise killifish Nothobranchius furzeri (Nfu) is a valid model for aging
studies. Here, we investigated its age-associated cardiac function. We observed oxidative …

Empagliflozin reduces the senescence of cardiac stromal cells and improves cardiac function in a murine model of diabetes

R Madonna, V Doria, I Minnucci, A Pucci… - Journal of Cellular …, 2020 - Wiley Online Library
The sodium‐glucose cotransporter 2 (SGLT2) inhibitor empagliflozin reduces heart failure in
diabetes, but underlying mechanisms remain elusive. We hypothesized that empagliflozin …

Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from type2 diabetes patients: rescue by α-ketoglutarate and TET-TDG functional …

F Spallotta, C Cencioni, S Atlante, D Garella… - Circulation …, 2018 - Am Heart Assoc
Rationale: Human cardiac mesenchymal cells (CMSCs) are a therapeutically relevant
primary cell population. Diabetes mellitus compromises CMSC function as consequence of …

Isolation and characterization of cardiac mesenchymal stromal cells from endomyocardial bioptic samples of arrhythmogenic cardiomyopathy patients

CA Pilato, I Stadiotti, AS Maione… - Journal of …, 2018 - pmc.ncbi.nlm.nih.gov
A normal adult heart is composed of several different cell types, among which cardiac
mesenchymal stromal cells represent an abundant population. The isolation of these cells …

Differences in mitochondrial membrane potential identify distinct populations of human cardiac mesenchymal progenitor cells

E Gambini, I Martinelli, I Stadiotti, MC Vinci… - International Journal of …, 2020 - mdpi.com
Adult human cardiac mesenchymal progenitor cells (hCmPC) are multipotent resident
populations involved in cardiac homeostasis and heart repair. Even if the mechanisms have …

Electrospun fibers of polyester, with both nano-and micron diameters, loaded with antioxidant for application as wound dressing or tissue engineered scaffolds

J Fernández, M Ruiz-Ruiz… - ACS Applied Polymer …, 2019 - ACS Publications
Antioxidant loaded poly (ε-caprolactone)(PCL) scaffolds were fabricated by electrospinning
and then tested–mechanically and characterized via microscopy imaging. These mats are …

Cardiac nonmyocyte subpopulations: a secular congregation

MA Sussman - Regenerative medicine, 2019 - Taylor & Francis
Conclusion Analyses using freshly isolated CNon-MS have fundamental importance for
understanding myocardial biology in development, injury, and aging, as well as effects of …

Cardiac stromal cells on stage. From dull filler to specialized actors

V Picchio, F Pagano, I Chimenti - Biocell, 2022 - iris.uniroma1.it
Cardiac stromal cells have faced through the years a significant evolution in their definitions
concerning their phenotypes, markers, and functions. They are surging to key roles in …