Glutamine‐derived peptides: Current progress and future directions

T Yu, T Hu, K Na, L Zhang, S Lu… - … Reviews in Food …, 2024 - Wiley Online Library
Glutamine, the most abundant amino acid in the body, plays a critical role in preserving
immune function, nitrogen balance, intestinal integrity, and resistance to infection. However …

[HTML][HTML] In Vivo and In Vitro Models of Hepatic Fibrosis for Pharmacodynamic Evaluation and Pathology Exploration

Y Hu, Z Zhang, A Adiham, H Li, J Gu… - International Journal of …, 2025 - mdpi.com
Hepatic fibrosis (HF) is an important pathological state in the progression of chronic liver
disease to end-stage liver disease and is usually triggered by alcohol, nonalcoholic fatty …

Alanyl-Glutamine Dipeptide attenuates non-alcoholic fatty liver Disease Induced by a high-Fat Diet in mice by improving gut microbiota dysbiosis

Y Zheng, H Ying, J Shi, L Li, Y Zhao - Nutrients, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) manifests as a persistent liver ailment marked by
the excessive buildup of lipids within the hepatic organ accompanied by inflammatory …

[HTML][HTML] Liver lipid metabolism, oxidative stress, and inflammation in glutamine-supplemented ob/ob mice

JSM Leite, EA Vilas-Boas, HK Takahashi… - The Journal of …, 2025 - Elsevier
Glutamine availability may be reduced in chronic diseases, such as type 2 diabetes mellitus
(T2DM)-induced by obesity. Herein, the antioxidant, anti-inflammatory and lipid metabolism …

Influence of the glutamate-glutamine cycle on valproic acid-associated hepatotoxicity in pediatric patients with epilepsy

L Ma, J Zhu, X Kong, L Chen, J Du, L Yang… - Clinical …, 2024 - Taylor & Francis
Introduction Although valproic acid is generally well tolerated, hepatotoxicity is a common
side effect in patients receiving long-term treatment. However, the mechanisms underlying …

[HTML][HTML] CD36 in liver diseases

Y Liu, W Yin - Hepatology Communications, 2025 - journals.lww.com
Abstract Cluster of differentiation 36 (CD36) is a transmembrane glycoprotein with the ability
to bind to multiple ligands and perform diverse functions. Through the recognition of long …

Citrullus mucosospermus Extract Exerts Protective Effects against Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis in Mice

SY Park, JE Kim, HM Kang, KH Park, BI Je, KW Lee… - Foods, 2024 - mdpi.com
In recent years, there has been increasing interest in exploring the potential therapeutic
advantages of Citrullus mucosospermus extracts (CME) for nonalcoholic steatohepatitis …

Phosphorylation site of L-alanyl-L-glutamine identified by Raman optical activity spectroscopy

T Wu, J Kessler, H Zhao, Y Zhao - … Acta Part A: Molecular and Biomolecular …, 2024 - Elsevier
Phosphorylated peptides are instrumental in studying protein phosphorylation events. In the
present study, Raman optical activity (ROA) is employed to elucidate the structure of a …

Protective effects of syringic acid in nonalcoholic fatty liver in rats through regulation of Nrf2/HO‐1 signaling pathway

S Zhang, S Zheng, Y Li, J Yang, X Mao… - … of Biochemical and …, 2024 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is an alarming ailment that leads to severe liver
damage and increases the risk of serious health conditions. The prevalence of NAFLD due …