Nanomaterial-based therapeutics for antibiotic-resistant bacterial infections

JMV Makabenta, A Nabawy, CH Li… - Nature Reviews …, 2021 - nature.com
Antibiotic-resistant bacterial infections arising from acquired resistance and/or through
biofilm formation necessitate the development of innovative 'outside of the box'therapeutics …

Nanotechnology-based antimicrobials and delivery systems for biofilm-infection control

Y Liu, L Shi, L Su, HC van der Mei, PC Jutte… - Chemical Society …, 2019 - pubs.rsc.org
Bacterial-infections are mostly due to bacteria in an adhering, biofilm-mode of growth and
not due to planktonically growing, suspended-bacteria. Biofilm-bacteria are much more …

Surface-Adaptive Gold Nanoparticles with Effective Adherence and Enhanced Photothermal Ablation of Methicillin-Resistant Staphylococcus aureus Biofilm

D Hu, H Li, B Wang, Z Ye, W Lei, F Jia, Q Jin, KF Ren… - ACS …, 2017 - ACS Publications
Biofilms that contribute to the persistent bacterial infections pose serious threats to global
public health, mainly due to their resistance to antibiotics penetration and escaping innate …

Nanoparticle–biofilm interactions: the role of the EPS matrix

S Fulaz, S Vitale, L Quinn, E Casey - Trends in microbiology, 2019 - cell.com
The negative consequences of biofilms are widely reported. A defining feature of biofilms is
the extracellular matrix, a complex mixture of biomacromolecules, termed EPS, which …

Self-propelled active photothermal nanoswimmer for deep-layered elimination of biofilm in vivo

T Cui, S Wu, Y Sun, J Ren, X Qu - Nano Letters, 2020 - ACS Publications
Increasing penetration of antibacterial agents into biofilm is a promising strategy for
improvement of therapeutic effect and slowdown of the progression of antibiotic resistance …

Porphyrin MOF dots–based, function‐adaptive nanoplatform for enhanced penetration and photodynamic eradication of bacterial biofilms

Q Deng, P Sun, L Zhang, Z Liu, H Wang… - Advanced Functional …, 2019 - Wiley Online Library
Recently, antimicrobial photodynamic therapy (aPDT) has been considered as an attractive
treatment option for biofilms ablation. However, even very efficient photosensitizers (PSs) …

Progress and prospects of nanomaterials against resistant bacteria

J He, M Hong, W Xie, Z Chen, D Chen, S Xie - Journal of Controlled …, 2022 - Elsevier
Drug-resistant bacterial infections are increasingly heightening, which lead to more severe
illness, higher cost of treatment and increased risk of death. Nanomaterials-based therapy …

[HTML][HTML] Promising therapeutic strategies against microbial biofilm challenges

K Zhang, X Li, C Yu, Y Wang - Frontiers in Cellular and Infection …, 2020 - frontiersin.org
Biofilms are communities of microorganisms that are attached to a biological or abiotic
surface and are surrounded by a self-produced extracellular matrix. Cells within a biofilm …

Synthetic antimicrobial polymers in combination therapy: tackling antibiotic resistance

R Namivandi-Zangeneh, EHH Wong… - ACS Infectious …, 2021 - ACS Publications
Antibiotic resistance is a critical global healthcare issue that urgently needs new effective
solutions. While small molecule antibiotics have been safeguarding us for nearly a century …

[HTML][HTML] Microbial resistance to nanotechnologies: An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants

Z Wu, B Chan, J Low, JJH Chu, HWD Hey, A Tay - Bioactive Materials, 2022 - Elsevier
Microbial resistance to current antibiotics therapies is a major cause of implant failure and
adverse clinical outcomes in orthopaedic surgery. Recent developments in advanced …