[HTML][HTML] Trajectories and contributing factors of neural compensation in healthy and pathological aging
Neural degeneration is a hallmark of healthy aging and can be associated with specific
cognitive impairments. However, neural degeneration per se is not matched by unremitting …
cognitive impairments. However, neural degeneration per se is not matched by unremitting …
Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology
Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …
a significant global health challenge as well as a high socioeconomic burden. With aging …
The microcircuits of striatum in silico
JJJ Hjorth, A Kozlov, I Carannante… - Proceedings of the …, 2020 - National Acad Sciences
The basal ganglia play an important role in decision making and selection of action primarily
based on input from cortex, thalamus, and the dopamine system. Their main input structure …
based on input from cortex, thalamus, and the dopamine system. Their main input structure …
[HTML][HTML] Virtual deep brain stimulation: Multiscale co-simulation of a spiking basal ganglia model and a whole-brain mean-field model with The Virtual Brain
JM Meier, D Perdikis, A Blickensdörfer… - Experimental …, 2022 - Elsevier
Deep brain stimulation (DBS) has been successfully applied in various neurodegenerative
diseases as an effective symptomatic treatment. However, its mechanisms of action within …
diseases as an effective symptomatic treatment. However, its mechanisms of action within …
Dysfunction of motor cortices in Parkinson's disease
The cerebral cortex has long been thought to be involved in the pathophysiology of motor
symptoms of Parkinson's disease. The impaired cortical function is believed to be a direct …
symptoms of Parkinson's disease. The impaired cortical function is believed to be a direct …
The digital twin brain: A bridge between biological and artificial intelligence
In recent years, advances in neuroscience and artificial intelligence have paved the way for
unprecedented opportunities to understand the complexity of the brain and its emulation …
unprecedented opportunities to understand the complexity of the brain and its emulation …
A comprehensive meta-analysis on short-term and working memory dysfunction in Parkinson's disease
A previous meta-analysis demonstrated short-term memory (STM) and working memory
(WM) dysfunction in patients with Parkinson's disease (PD). However, considerable …
(WM) dysfunction in patients with Parkinson's disease (PD). However, considerable …
Quantifying harmony between direct and indirect pathways in the basal ganglia: healthy and Parkinsonian states
SY Kim, W Lim - Cognitive Neurodynamics, 2024 - Springer
The basal ganglia (BG) show a variety of functions for motor and cognition. There are two
competitive pathways in the BG; direct pathway (DP) which facilitates movement and indirect …
competitive pathways in the BG; direct pathway (DP) which facilitates movement and indirect …
Hopf bifurcation analysis for Parkinson oscillation with heterogeneous delays: A theoretical derivation and simulation analysis
Z Wang, B Hu, L Zhu, J Lin, M Xu, D Wang - Communications in Nonlinear …, 2022 - Elsevier
In this paper, we systematically study Parkinson oscillation origin mechanism, oscillation
amplitude and frequency characteristics in an improved cortex-basal ganglia (EXN-INN-STN …
amplitude and frequency characteristics in an improved cortex-basal ganglia (EXN-INN-STN …
[HTML][HTML] EEG, MEG and neuromodulatory approaches to explore cognition: Current status and future directions
Neural oscillations and their association with brain states and cognitive functions have been
object of extensive investigation over the last decades. Several electroencephalography …
object of extensive investigation over the last decades. Several electroencephalography …