The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

The mammalian family of two-pore domain K+ (K2P) channel proteins are encoded by 15
KCNK genes and subdivided into six subfamilies on the basis of sequence similarities …

Objective: The biophysical properties and the regulation of the two-pore-domain potassium
channel TREK-1 were studied in rat cardiomyocytes. Methods: RT-PCR …

Two-pore-domain potassium (K2P-) channels conduct outward K+ currents that maintain the
resting membrane potential and modulate action potential repolarization. Members of the …

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the (n-3) PUFA found in
fish oils, exert antiarrhythmic effects during ischemia. Flaxseed is the richest plant source of …

Two-pore domain (K 2P) channels emerged about a decade ago and since then have been
an expanding area of interest. This is because their biophysical and pharmacological …

The heart is a mechanically-active organ that dynamically senses its own mechanical
environment. This environment is constantly changing, on a beat-by-beat basis, with …

Background Two‐pore K+ channels have emerged as potential targets to selectively
regulate cardiac cell membrane excitability; however, lack of specific inhibitors and relevant …

Abstract TWIK-related K+ channel (TREK-1) two-pore-domain potassium (K 2P) channels
mediate background potassium currents and regulate cellular excitability in many different …