The cullin-RING E3 ubiquitin ligase CRL4 Cdt2 has emerged as a master regulator of
genome stability, which targets key cell cycle proteins for proteolysis during S phase and …

Understanding protein dynamics is crucial in order to elucidate protein function and
interactions. Advances in modern microscopy facilitate the exploration of the mobility of …

The maintenance of genome integrity is essential for cellular survival and propagation. It
relies upon the accurate and timely replication of the genetic material, as well as the rapid …

Proliferation of cells under hypoxia is facilitated by metabolic adaptation, mediated by the
transcriptional activator Hypoxia Inducible Factor-1 (HIF-1). HIF-1α, the inducible subunit of …

Membrane blebs are specialized cellular protrusions that play diverse roles in processes
such as cell division and cell migration. Blebbing can be divided into three distinct phases …

Fluorescence recovery after photobleaching (FRAP) is a cutting-edge live-cell functional
imaging technique that enables the exploration of protein dynamics in individual cells and …

The CRL4Cdt2 ubiquitin ligase complex is an essential regulator of cell-cycle progression
and genome stability, ubiquitinating substrates such as p21, Set8, and Cdt1, via a display of …

Force generation by the molecular motor myosin II (MII) at the actin cortex is a universal
feature of animal cells. Despite its central role in driving cell shape changes, the …

Fluorescence recovery after photobleaching (FRAP) is a laser method of light microscopy to
evaluate the rapid movement of fluorescent molecules. To have a more reliable approach to …

DNA replication is a complex and remarkably robust process: despite its inherent
uncertainty, manifested through stochastic replication timing at a single-cell level, multiple …