Rho GTPases play an essential role in regulating cell spreading, adhesion, and migration
downstream of integrin engagement with the extracellular matrix. In this review, we focus on …

Cancer progression and metastasis are processes that involve significant cellular changes.
Many of these changes include alterations in the activity of the Rho GTPase family of …

RHO GTPase-activating proteins (RHOGAPs) are one of the major classes of regulators of
the RHO-related protein family that are crucial in many cellular processes, motility …

The basal-like breast cancer (BLBC) subtype accounts for a disproportionately high
percentage of overall breast cancer mortality. The current therapeutic options for BLBC need …

Rac GTPase activating protein 1 (RacGAP1) can regulate cytokinesis and cell differentiation.
The oncogenic role of RacGAP1 has been partially studied in gastric cancer, colorectal …

Platelet cytoskeletal reorganisation is a critical component of platelet activation and
thrombus formation in haemostasis. The Rho GTPases RhoA, Rac1 and Cdc42 are the …

The RHO family of RAS-related GTPases in tumors may be activated by reduced levels of
RHO GTPase accelerating proteins (GAPs). One common mechanism is decreased …

Invasive duct carcinoma (IDC) is one of the most common types of breast cancer (BC) in
women worldwide, with a high risk of malignancy, metastasis, recurrence, and death. So far …

Background The molecular signaling events involving in high malignancy and poor
prognosis of hepatocellular carcinoma (HCC) are extremely complicated. Blockade of …

Like RAS proteins, the aberrant function of RHO family small GTPases has been implicated
in driving cancer development and growth. However, unlike the RAS family, where gain-of …