In vivo medical imaging has made great progress due to advances in the engineering of
imaging devices and developments in the chemistry of imaging probes. Several modalities …

The β-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease involved
in Alzheimer's disease (AD) pathogenesis and in myelination. BACE1 initiates the …

Increased proteolytic activity is a hallmark of several pathological processes, including
neurodegeneration. Increased expression and activity of cathepsins, lysosomal cysteine …

Abstract Sirtuin-1 (SIRT1) regulates hepatic metabolism but its contribution to NF-κB-
dependent inflammation has been overlooked. Cysteine cathepsins (Cathepsin B or S …

Cathepsins (CTSs) are ubiquitously expressed proteases normally found in the
endolysosomal compartment where they mediate protein degradation and turnover …

Neuroinflammation and excessive β-amyloid 1–42 (Aβ 1–42) generation contribute to the
pathogenesis of Alzheimer's disease (AD). Emerging evidence has demonstrated that …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, Huntington's disease and prion disease are not timely and …

Proteins are susceptible to numerous non-enzymatic post-translational modifications which
occur both during normal aging and in neurodegenerative states. For instance, formation of …

The insulin-like growth factor II/mannose 6-phosphate (IGF-II/M6P) receptor is a
multifunctional single transmembrane glycoprotein. Recent studies have advanced our …

Neuroinflammation, which is mediated by microglia and astrocytes, is associated with the
progression of neurodegenerative diseases. Increasing evidence shows that activated …