Triple negative breast cancer (TNBC), which is typically lack of expression of estrogen
receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 …

Triple-negative breast cancer (TNBC) is the most complex, aggressive and fatal subtype of
breast cancer. Owing to the lack of targeted therapy and heterogenic nature of TNBC …

Heat shock proteins are essential molecular chaperones that play crucial roles in stabilizing
protein structures, facilitating the repair or degradation of damaged proteins, and …

Abstract The 90-kiloDalton (kD) heat shock protein (Hsp90) is a ubiquitous, ATP-dependent
molecular chaperone whose primary function is to ensure the proper folding of several …

Activating mutations of epidermal growth factor receptor (EGFR) play crucial roles in the
oncogenesis of human non-small cell lung cancer (NSCLC). By screening 79 commercially …

Deguelin is a rotenoid of the flavonoid family, which can be extracted from Lonchocarpus,
Derris, or Tephrosia. It possesses the inhibition of cancer cell proliferation by inducing …

Although active targeting liposomes with cancer-specific ligands can bind and internalize
into cancer cells, only a few high-efficiency liposomes have been developed so far because …

A pharmacophore-hybridized strategy based on previously reported HSP90 C-terminal
inhibitors was utilized to prepare 32 aryl/penta-1, 4-dien-3-one/amine hybrids. Among them …

Background Pancreatic cancer has a high degree of malignancy and high mortality.
Understanding its biological status can provide more therapeutic targets for the future. The …

A series of O-substituted analogs of the C-ring-truncated scaffold of deguelin designed as
heat shock protein 90 (HSP90) C-terminal inhibitors were investigated as novel antitumor …