Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Estrogen deficiency has been considered the seminal mechanism of osteoporosis in both
women and men, but epidemiological evidence in humans and recent mechanistic studies …

Photodynamic therapy (PDT) has been proposed in cancer treatment for decades, but its
clinical translation is significantly impeded by the low yield of ROS, poor tissue penetration …

Photodynamic therapy (PDT) is a well-established modality for cancer therapy, which locally
kills cancer cells when light irradiates a photosensitizer. However, conventional PDT is often …

Mitochondrial dysfunctions are supposed to be responsible for many neurodegenerative
diseases dominating in Alzheimer's disease (AD), Parkinson's disease (PD), and …

Depressive disorders are heterogeneous diseases, and the complexity of symptoms has led
to the formulation of several aethiopathological hypotheses. This heterogeneity may account …

Reduced glutathione (L-γ-glutamyl-L-cysteinyl-glycine, GSH) is the prevalent low-molecular-
weight thiol in mammalian cells. It is formed in a two-step enzymatic process including, first …

Granzyme A (GzmA) triggers cell death with apoptotic features by targeting the endoplasmic
reticulum-associated SET complex, which contains the GzmA-activated DNase NM23-H1, its …

Estrogens attenuate osteoclastogenesis and stimulate osteoclast apoptosis, but the
molecular mechanism and contribution of these effects to the overall antiosteoporotic …

Lymphocyte traffic is required to maintain homeostasis and perform appropriate
immunological reactions. To migrate into inflamed tissues, lymphocytes must acquire spatial …