Psilocybin is found in a family of mushrooms commonly known as “magic mushrooms” that
have been used throughout history to induce hallucinations. In the late 1950s Albert …

Aims As an analgesic that acts upon the central nervous system (CNS), tramadol has gained
popularity in treating moderate to severe pain. Recently, it has been increasingly reported as …

In vitro microelectrode array (MEA) assessment using human induced pluripotent stem cell
(iPSC)-derived neurons holds promise as a method of seizure and toxicity evaluation …

Poisoning with opioid analgesics including tramadol represents a challenge. Tramadol may
induce respiratory depression, seizures and serotonin syndrome, possibly worsened when …

Context: Since the banning of dextropropoxyphene from the market, overdoses, and
fatalities attributed to tramadol, a WHO step-2 opioid analgesic, have increased markedly …

There is an increasing demand for effective treatments for depression, particularly for
individuals grappling with treatment-resistant depression. Over recent years, a surge of …

Abstract Background Non-medical Prescription Opioid Use (NMPOU) has increased
worldwide during the last decades, and specifically, tramadol misuse may represent a novel …

Classical psychedelics represent a family of psychoactive substances with structural
similarities to serotonin and affinity for serotonin receptors. A growing number of studies …

1-cyclohexyl-x-methoxybenzene is a novel psychoactive substance (NPS), first discovered
in Europe in 2012 as unknown racemic mixture of its three stereoisomers: ortho, meta and …

Drugs with potential to lower the seizure threshold are numerous and diverse. Whether they
contribute to clinically overt seizures depends on the dosage in which they are taken, the …