Beneficial effects of citrus flavonoids on cardiovascular and metabolic health

AM Mahmoud, RJ Hernandez Bautista… - Oxidative medicine …, 2019 - Wiley Online Library
The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a
comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess …

[HTML][HTML] Quinoa secondary metabolites and their biological activities or functions

M Lin, P Han, Y Li, W Wang, D Lai, L Zhou - Molecules, 2019 - mdpi.com
Quinoa (Chenopodium quinoa Willd.) was known as the “golden grain” by the native
Andean people in South America, and has been a source of valuable food over thousands …

Naringin protects against cyclophosphamide-induced hepatotoxicity and nephrotoxicity through modulation of oxidative stress, inflammation, apoptosis, autophagy …

C Caglayan, Y Temel, FM Kandemir, S Yildirim… - … Science and Pollution …, 2018 - Springer
Cyclophosphamide (CP) is a common chemotherapeutic agent that is effective against a
wide variety of tumors. The associated hepatotoxicity and nephrotoxicity, however, limit its …

[HTML][HTML] Galangin activates Nrf2 signaling and attenuates oxidative damage, inflammation, and apoptosis in a rat model of cyclophosphamide-induced hepatotoxicity

SH Aladaileh, MH Abukhalil, SAM Saghir, H Hanieh… - Biomolecules, 2019 - mdpi.com
Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical
application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive …

Orange fruit (Citrus sinensis) peel extract attenuates chemotherapy-induced toxicity in male rats

EA Abdelghffar, HAS El-Nashar, AGA Al-Mohammadi… - Food & function, 2021 - pubs.rsc.org
Background: Cyclophosphamide (CYP) is a chemotherapy drug widely used in the treatment
of several types of cancers and autoimmune disorders. Unfortunately, it causes severe side …

Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats

AM Mahmoud, WG Hozayen, SM Ramadan - Biomedicine & …, 2017 - Elsevier
Berberine (BBR) is a natural isoquinoline alkaloid with very impressive health benefits. It is
one of the most effective natural supplements available; however, its ameliorative …

Potential anti-inflammatory effects of hesperidin from the genus citrus

S Tejada, S Pinya, M Martorell, X Capó… - Current medicinal …, 2018 - ingentaconnect.com
Background: The benefits of the Mediterranean diet for protecting against many diseases
are usually attributed to high consumption of certain foods, characterized by the presence of …

[PDF][PDF] Ethanolic extract of capparis decidua fruit ameliorates methotrexate-induced hepatotoxicity by activating Nrf2/HO-1 and PPARγ mediated pathways

P Santhakumar, A Roy, KG Mohanraj… - Ind J Pharm …, 2021 - pdfs.semanticscholar.org
Introduction: Methotrexate, a folate antimetabolite, immunosuppressant and cytotoxic
chemotherapeutic agents employed for malignant conditions. Continuous exposure of …

[HTML][HTML] Olea europaea leaf extract up-regulates Nrf2/ARE/HO-1 signaling and attenuates cyclophosphamide-induced oxidative stress, inflammation and apoptosis in …

HAS ALHaithloul, MF Alotaibi, M Bin-Jumah… - Biomedicine & …, 2019 - Elsevier
Olive leaf extract (OLE) has potential health benefits and protects against cytotoxicity in
different organs. However, nothing has yet been reported on its potential to prevent …

Possible involvement of Nrf2 and PPARγ up-regulation in the protective effect of umbelliferone against cyclophosphamide-induced hepatotoxicity

AM Mahmoud, MO Germoush, MF Alotaibi… - Biomedicine & …, 2017 - Elsevier
Umbelliferone (UMB) is a coumarin derivative with promising hepatoprotective effects. In this
study, we examined the possible protective effects of UMB against cyclophosphamide (CP) …