Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology

OD Howes, M Rogdaki, JL Findon… - Journal of …, 2018 - journals.sagepub.com
An expert review of the aetiology, assessment, and treatment of autism spectrum disorder,
and recommendations for diagnosis, management and service provision was coordinated …

Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care?

M Colizzi, A Lasalvia, M Ruggeri - International journal of mental health …, 2020 - Springer
Background Similar to other health care sectors, mental health has moved towards the
secondary prevention, with the effort to detect and treat mental disorders as early as …

Advancing models of neural development with biomaterials

JG Roth, MS Huang, TL Li, VR Feig, Y Jiang… - Nature Reviews …, 2021 - nature.com
Human pluripotent stem cells have emerged as a promising in vitro model system for
studying the brain. Two-dimensional and three-dimensional cell culture paradigms have …

Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance spectroscopy study in man and rodent models

J Horder, MM Petrinovic, MA Mendez, A Bruns… - Translational …, 2018 - nature.com
Autism spectrum disorder (ASD) is a pervasive neurodevelopmental syndrome with a high
human and economic burden. The pathophysiology of ASD is largely unclear, thus …

Altering the course of schizophrenia: progress and perspectives

MJ Millan, A Andrieux, G Bartzokis… - Nature reviews Drug …, 2016 - nature.com
Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

Progress in the genetics of autism spectrum disorder

M Woodbury‐Smith, SW Scherer - Developmental Medicine & …, 2018 - Wiley Online Library
A genetic basis for autism spectrum disorder (ASD) is now well established, and with the
availability of high‐throughput microarray and sequencing platforms, major advances have …

Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse

KY Choe, RAI Bethlehem, M Safrin, H Dong, E Salman… - Neuron, 2022 - cell.com
The neural basis of abnormal social behavior in autism spectrum disorders (ASDs) remains
incompletely understood. Here we used two complementary but independent brain-wide …

Human induced pluripotent stem cells for modelling neurodevelopmental disorders

K Ardhanareeswaran, J Mariani, G Coppola… - Nature Reviews …, 2017 - nature.com
We currently have a poor understanding of the pathogenesis of neurodevelopmental
disorders, owing to the fact that postmortem and imaging studies can only measure the …

Identification and validation of biomarkers for autism spectrum disorders

E Loth, W Spooren, LM Ham, MB Isaac… - Nature reviews Drug …, 2016 - nature.com
(DSM5), the core symptoms of ASD comprise deficits in social communication and inter
action, and repetitive and restricted behaviours, which include sensory abnormalities. Novel …