Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

The pathogenesis of dengue virus infection is attributed to complex interplay between virus,
host genes and host immune response. Host factors such as antibody-dependent …

Mortality from severe dengue is low, but the economic and resource burden on health
services remains substantial in endemic settings. Unfortunately, progress towards …

RIG‐I is our first line of defense against RNA viruses, serving as a pattern recognition
receptor that identifies molecular features common among dsRNA and ssRNA viral …

RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …

Zika virus (ZIKV), a previously obscure flavivirus closely related to dengue, West Nile,
Japanese encephalitis and yellow fever viruses, has emerged explosively since 2007 to …

Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a
multitude of cellular processes. Studies in recent years have demonstrated that many TRIM …

The co-evolution of viruses with their hosts has led to the emergence of viral pathogens that
are adept at evading or actively suppressing host immunity. Pattern recognition receptors …