Pharmacological targeting of mitochondrial ion channels is emerging as a promising approach to eliminate cancer cells; as most of these channels are differentially expressed …
A Remigante, S Spinelli, A Marino, M Pusch… - International Journal of …, 2023 - mdpi.com
Oxidative stress and immune response play an important role in the development of several cancers, including melanoma. Ion channels are aberrantly expressed in tumour cells and …
AL Capatina, D Lagos, WJ Brackenbury - Targets of Cancer Diagnosis and …, 2020 - Springer
Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety of processes such as maintenance of cellular osmolarity and membrane potential, motility …
The field of mitochondrial ion channels underwent a rapid development during the last decade, thanks to the molecular identification of some of the nuclear-encoded organelle …
A Urbani, E Prosdocimi, A Carrer… - Frontiers in cell and …, 2021 - frontiersin.org
Mitochondria are bioenergetic organelles with a plethora of fundamental functions ranging from metabolism and ATP production to modulation of signaling events leading to cell …
In this paper, the current challenges of mitochondrial potassium channels research were critically reviewed. Even though recent progress in understanding K+ traffic in mitochondria …
The field of mitochondrial ion channels has undergone a rapid development during the last three decades, due to the molecular identification of some of the channels residing in the …
V Checchetto, E Teardo, L Carraretto, L Leanza… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Plasma membrane potassium channels importantly contribute to maintain ion homeostasis across the cell membrane. The view is emerging that also those residing in intracellular …
X Fan, Y Lu, G Du, J Liu - Molecules, 2022 - mdpi.com
TWIK-related acid-sensitive K+ (TASK) channels, including TASK-1, TASK-3, and TASK-5, are important members of the two-pore domain potassium (K2P) channel family. TASK-5 is …