Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells
and differentiated cells suggests global chromatin remodelling during differentiation, which …

Post-translational modifications (PTMs) are known to be essential mechanisms used by
eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling …

Heterogeneity is an omnipresent feature of mammalian cells in vitro and in vivo. It has been
recently realized that even mouse and human embryonic stem cells under the best culture …

Pluripotent stem cells (PSCs) are capable of dynamic interconversion between distinct
substates; however, the regulatory circuits specifying these states and enabling transitions …

Histone modifications influence the interactions of transcriptional regulators with chromatin.
Studies in embryos and embryonic stem (ES) cells have uncovered histone modification …

Studies using high-resolution genome-wide approaches have recently reported that
genomic and epigenomic alterations frequently accumulate in human pluripotent cells …

Detailed understanding of the pathogenesis and development of effective therapies for
pulmonary fibrosis (PF) have been hampered by lack of in vitro human models that …

The pluripotent nature of human embryonic stem cells (hESCs) makes them convenient for
deriving therapeutically relevant cells. Here we show using Wnt reporter hESC lines that the …

The cell cycle in pluripotent stem cells is notable for the brevity of the G1 phase, permitting
rapid proliferation and reducing the duration of differentiation signal sensitivity associated …

Developmental regulatory genes have both activating (H3K4me3) and repressive
(H3K27me3) histone modifications in embryonic stem cells (ESCs). This bivalent …