Elevated levels of the epidermal growth factor receptor (EGFR), a growth-factor-receptor
tyrosine kinase, and/or its cognate ligands have been identified as a common component of …

The'magic bullet'concept of specifically targeting cancer cells at the same time as sparing
normal tissues is now proven, as several monoclonal antibodies and targeted small …

Purpose Erlotinib is a potent inhibitor of the epidermal growth factor receptor tyrosine kinase,
with single-agent antitumor activity. Preclinically, erlotinib enhanced the cytotoxicity of …

Homeostasis of multicellular organisms is critically dependent on the correct interpretation of
the plethora of signals which cells are exposed to during their lifespan. Various soluble …

The anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibody cetuximab
specifically binds to the EGFR with high affinity, blocking growth-factor binding, receptor …

In multicellular organisms, communication between individual cells is essential for the
regulation and coordination of complex cellular processes such as growth, differentiation …

Molecular targeting strategies for cancer therapy are distinct from conventional
chemotherapy and radiotherapy in their potential to provide increased tumor specificity. One …

A new series of 1 H-pyrrole (6a–c, 8a–c), pyrrolo [3, 2-d] pyrimidines (9a–c) and pyrrolo [3, 2-
e][1, 4] diazepines (11a–c) were designed and synthesised. These compounds were …

We have recently demonstrated that molecular blockade of the epidermal growth factor
receptor with the anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 …

Highly migratory neuroectodermal cells share a common embryonic origin with cells of the
central nervous system (CNS). They include enteric, parasympathetic, sympathoadrenal …