Macromolecular transport between the cytoplasm and the nucleus occurs through the
nuclear pore complex (NPC) and is mediated by multiple families of soluble transport …

The kinetochore is a control module that both powers and regulates chromosome
segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably …

Importin β, once thought to be exclusively a nuclear transport receptor, is emerging as a
global regulator of diverse cellular functions. Importin β acts positively in multiple interphase …

RanGAP1 was the first documented substrate for conjugation with the ubiquitin-like protein
SUMO-1. However, the functional significance of this conjugation has not been fully clarified …

The vertebrate nuclear pore complex, 30 times the size of a ribosome, assembles from a
library of soluble subunits and two membrane proteins. Using immunodepletion of Xenopus …

Ran is a member of the Ras superfamily of proteins, which primarily regulates
nucleocytoplasmic trafficking and mediates mitosis by regulating spindle formation and …

Communication between the nucleus and cytoplasm occurs through large macromolecular
structures, the nuclear pores. Quantitative scanning transmission electron microscopy has …

Background: Many organisms undergo closed mitosis and locate tubulin and mitotic kinases
to nuclei only during mitosis. How this is regulated is unknown. Interestingly, the NIMA …

Small GTP-binding proteins represent a highly conserved signaling module in eukaryotes
that regulates diverse cellular processes such as signal transduction, cytoskeletal …

Small GTPase is a kind of GTP-binding protein commonly found in eukaryotic cells. It plays
an important role in cytoskeletal reorganization, cell polarity, cell cycle progression, gene …