The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …

Regulatory T (Treg) cells ensure tolerance against self-antigens, limit excessive
inflammation, and support tissue repair processes. Therefore, Treg cells are currently …

Engineered T cells represent an emerging therapeutic modality. However, complex
engineering strategies can present a challenge for enriching and expanding therapeutic …

Simple Summary Adoptive immunotherapy has emerged as an effective alternative of
mounting impact to the current standard of care in cancer, viral infections, and recently …

Modulating an immune response in opposite directions represents the holy grail in
allogeneic hematopoietic stem cell transplantation (allo-HSCT) to avoid insufficient reactivity …

Adeno-associated virus (AAV) gene therapy is making rapid strides owing to its wide range
of therapeutic applications. However, development of serious immune responses to the …

Regulatory T (Treg) cells are essential for maintaining self-immune tolerance. Reduced
numbers or functions of Treg cells have been involved in the pathogenesis of various …

Graft-versus-host disease (GVHD) is a significant complication following allogeneic
hematopoietic cell transplantation (allo-HCT), posing substantial risks to patient survival. In …

Suppression of pathogenic immune responses is a major goal in the prevention and
treatment of type 1 diabetes. Adoptive cell therapy using regulatory T cells (Tregs), a …