While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

Cells are exposed to various endogenous and exogenous insults that induce DNA damage,
which, if unrepaired, impairs genome integrity and leads to the development of various …

Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are the primary
pathways for repairing DNA double-strand breaks (DSBs) during interphase, whereas …

DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because
they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that …

Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause
DNA breaks. Whether mammalian DNA repair Pols efficiently use template ribonucleotides …

Targeted cancer therapies represent a milestone towards personalized treatment as they
function via inhibition of cancer-specific alterations. Polymerase θ (POLQ), an error-prone …

DNA double-strand breaks (DSBs) are induced by a variety of genotoxic agents, including
ionizing radiation and chemotherapy drugs for treating cancers. The elimination of DSBs …

Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs),
are initiated by end resection that generates 3′ single strands. This reaction is shared, at …

DNA double-strand breaks require repair or risk corrupting the language of life. To ensure
genome integrity and viability, multiple DNA double-strand break repair pathways function in …

Current approaches for inserting autonomous transgenes into the genome, such as CRISPR–
Cas9 or virus-based strategies, have limitations including low efficiency and high risk of …