Artificial intelligence in COVID-19 drug repurposing

Y Zhou, F Wang, J Tang, R Nussinov… - The Lancet Digital …, 2020 - thelancet.com
Drug repurposing or repositioning is a technique whereby existing drugs are used to treat
emerging and challenging diseases, including COVID-19. Drug repurposing has become a …

Accelerating antibiotic discovery through artificial intelligence

MCR Melo, JRMA Maasch… - Communications …, 2021 - nature.com
By targeting invasive organisms, antibiotics insert themselves into the ancient struggle of the
host-pathogen evolutionary arms race. As pathogens evolve tactics for evading antibiotics …

[PDF][PDF] In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

BJ Kagan, AC Kitchen, NT Tran, F Habibollahi… - Neuron, 2022 - cell.com
Integrating neurons into digital systems may enable performance infeasible with silicon
alone. Here, we develop DishBrain, a system that harnesses the inherent adaptive …

Machine learning in enzyme engineering

S Mazurenko, Z Prokop, J Damborsky - ACS Catalysis, 2019 - ACS Publications
Enzyme engineering plays a central role in developing efficient biocatalysts for
biotechnology, biomedicine, and life sciences. Apart from classical rational design and …

The application of deep learning in cancer prognosis prediction

W Zhu, L Xie, J Han, X Guo - Cancers, 2020 - mdpi.com
Deep learning has been applied to many areas in health care, including imaging diagnosis,
digital pathology, prediction of hospital admission, drug design, classification of cancer and …

[PDF][PDF] Predicting drug response and synergy using a deep learning model of human cancer cells

BM Kuenzi, J Park, SH Fong, KS Sanchez, J Lee… - Cancer cell, 2020 - cell.com
Most drugs entering clinical trials fail, often related to an incomplete understanding of the
mechanisms governing drug response. Machine learning techniques hold immense promise …

Multimodal learning with graphs

Y Ektefaie, G Dasoulas, A Noori, M Farhat… - Nature Machine …, 2023 - nature.com
Artificial intelligence for graphs has achieved remarkable success in modelling complex
systems, ranging from dynamic networks in biology to interacting particle systems in physics …

[HTML][HTML] From big data to precision medicine

T Hulsen, SS Jamuar, AR Moody, JH Karnes… - Frontiers in …, 2019 - frontiersin.org
For over a decade the term “Big data” has been used to describe the rapid increase in
volume, variety and velocity of information available, not just in medical research but in …

[PDF][PDF] Systems biology of cancer metastasis

Y Suhail, MP Cain, K Vanaja, PA Kurywchak… - Cell systems, 2019 - cell.com
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …

Recent progress in multienzymes co-immobilization and multienzyme system applications

S Ren, C Li, X Jiao, S Jia, Y Jiang, M Bilal… - Chemical Engineering …, 2019 - Elsevier
Enzyme catalysis has been attracting increasing interest in the past twenty years.
Nevertheless, most reports concerning enzyme catalysis have been carried out using single …