Conjugated linoleic acid effects on cancer, obesity, and atherosclerosis: A review of pre-clinical and human trials with current perspectives

LJ den Hartigh - Nutrients, 2019 - mdpi.com
Obesity and its comorbidities, including type 2 diabetes and cardiovascular disease, are
straining our healthcare system, necessitating the development of novel strategies for weight …

Advances in fatty acids nutrition in dairy cows: from gut to cells and effects on performance

M Bionaz, E Vargas-Bello-Pérez, S Busato - Journal of Animal Science …, 2020 - Springer
High producing dairy cows generally receive in the diet up to 5–6% of fat. This is a relatively
low amount of fat in the diet compared to diets in monogastrics; however, dietary fat is …

Biosynthesis of milk fat, protein, and lactose: roles of transcriptional and posttranscriptional regulation

JS Osorio, J Lohakare, M Bionaz - Physiological genomics, 2016 - journals.physiology.org
The demand for high-quality milk is increasing worldwide. The efficiency of milk synthesis
can be improved by taking advantage of the accumulated knowledge of the transcriptional …

Conjugated linoleic acid: A potent fatty acid linked to animal and human health

P Shokryazdan, MA Rajion, GY Meng… - Critical Reviews in …, 2017 - Taylor & Francis
Conjugated linoleic acid (CLA) is a mixture of isomers of linoleic acid (C18: 2 n-6), which is
mostly found in the ruminant meat and dairy products. The CLA is known to have many …

Transcriptome profile analysis of adipose tissues from fat and short-tailed sheep

X Wang, G Zhou, X Xu, R Geng, J Zhou, Y Yang… - Gene, 2014 - Elsevier
Recent studies in domestic animals have used RNA-seq to explore the transcriptome of
different tissues in a limited number of individuals. In the present study, de novo …

[HTML][HTML] Assembly of novel sequences for Chinese domestic pigs reveals new genes and regulatory variants providing new insights into their diversity

H Du, C Diao, Y Zhuo, X Zheng, Z Hu, S Lu, W Jin… - Genomics, 2024 - Elsevier
There is an increasing understanding that a reference genome representing an individual
cannot capture all the gene repertoire of a species. Here, we conduct a population-scale …

Regulation of peroxisome proliferator-activated receptor gamma on milk fat synthesis in dairy cow mammary epithelial cells

L Liu, Y Lin, L Liu, L Wang, Y Bian, X Gao… - In Vitro Cellular & …, 2016 - Springer
Peroxisome proliferator-activated receptor gamma (PPARγ) participates in lipogenesis in
rats, goats, and humans. However, the exact mechanism of PPARγ regulation on milk fat …

[HTML][HTML] Trans-10, cis-12 conjugated linoleic acid alters lipid metabolism of goat mammary epithelial cells by regulation of de novo synthesis and the AMPK signaling …

TY Zhang, JT Huang, HB Tian, Y Ma, Z Chen… - Journal of dairy …, 2018 - Elsevier
ABSTRACT The trans-10, cis-12 isomer of conjugated linoleic acid (t10c12-CLA) is a
biohydrogenation intermediate in the rumen and has been shown to cause milk fat …

When Two plus Two Is More than Four: Evidence for a Synergistic Effect of Fatty Acids on Peroxisome Proliferator—Activated Receptor Activity in a Bovine Hepatic …

S Busato, M Bionaz - Genes, 2021 - mdpi.com
The inclusion of fat in livestock diets represents a valuable and cost-effective way to
increase the animal's caloric intake. Beyond their caloric value, fatty acids can be …

[HTML][HTML] Potential involvement of peroxisome proliferator-activated receptors in the inhibition of mammary lipid synthesis during diet-induced milk fat depression

A Haile, DE Oliveira, YR Boisclair, DE Bauman… - Journal of Dairy …, 2025 - Elsevier
The objective of this study was to evaluate the possible role of the peroxisome proliferator-
activated receptors (PPAR: PPAR-α, PPAR-β/δ, and PPAR-γ) in diet and CLA-induced milk …