[HTML][HTML] Role of microRNAs in COVID-19 with implications for therapeutics

N Arghiani, T Nissan, MM Matin - Biomedicine & Pharmacotherapy, 2021 - Elsevier
COVID-19 is a pneumonia-like disease with highly transmittable and pathogenic properties
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects …

SARS-CoV-2-associated organs failure and inflammation: a focus on the role of cellular and viral microRNAs

R Rasizadeh, PS Aghbash, JS Nahand… - Virology journal, 2023 - Springer
SARS-CoV-2 has been responsible for the recent pandemic all over the world, which has
caused many complications. One of the hallmarks of SARS-CoV-2 infection is an induced …

Mitochondrial reactive oxygen species mediate lysophosphatidylcholine-induced endothelial cell activation

X Li, P Fang, Y Li, YM Kuo, AJ Andrews… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Hyperlipidemia-induced endothelial cell (EC) activation is considered as an
initial event responsible for monocyte recruitment in atherogenesis. However, it remains …

Interleukin-17A promotes aortic endothelial cell activation via transcriptionally and post-translationally activating p38 mitogen-activated protein kinase (MAPK) …

J Mai, G Nanayakkara, J Lopez-Pastrana, X Li… - Journal of Biological …, 2016 - ASBMB
Interleukin-17 (IL-17)-secreting T helper 17 cells were recently identified as a CD4+ T helper
subset and implicated in various inflammatory and autoimmune diseases. The issues of …

Mitochondrial ROS, uncoupled from ATP synthesis, determine endothelial activation for both physiological recruitment of patrolling cells and pathological recruitment …

X Li, P Fang, WY Yang, K Chan… - Canadian journal of …, 2017 - cdnsciencepub.com
Mitochondrial reactive oxygen species (mtROS) are signaling molecules, which drive
inflammatory cytokine production and T cell activation. In addition, cardiovascular diseases …

SARS-CoV-2 proteins exploit host's genetic and epigenetic mediators for the annexation of key host signaling pathways

MAAK Khan, ABMMK Islam - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The constant rise of the death toll and cases of COVID-19 has made this pandemic a serious
threat to human civilization. Understanding of host-SARS-CoV-2 interaction in viral …

Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt

PA Erice, X Huang, MJ Seasock, MJ Robertson… - Elife, 2024 - elifesciences.org
Environmental air irritants including nanosized carbon black (nCB) can drive systemic
inflammation, promoting chronic obstructive pulmonary disease (COPD) and emphysema …

MicroRNAs as novel regulators of neuroinflammation

DJ Ksiazek-Winiarek, MJ Kacperska… - Mediators of …, 2013 - Wiley Online Library
MicroRNAs are relatively recently discovered class of small noncoding RNAs, which function
as important regulators of gene expression. They fine‐tune protein expression either by …

IL-17A as a potential therapeutic target for patients on peritoneal dialysis

V Marchant, A Tejera-Muñoz, L Marquez-Expósito… - Biomolecules, 2020 - mdpi.com
Chronic kidney disease (CKD) is a health problem reaching epidemic proportions. There is
no cure for CKD, and patients may progress to end-stage renal disease (ESRD). Peritoneal …

Association between long noncoding RNA taurine‐upregulated gene 1 and microRNA‐377 in vitiligo

M Alhelf, LA Rashed, N Ragab, MF Elmasry - 2022 - Wiley Online Library
Background Taurine‐upregulated gene 1 (TUG1) is one of the long noncoding RNAs
(lncRNAs) that plays a role in melanogenesis. MicroRNA‐377 (miRNA‐377) is a conserved …