Perineural invasion (PNI) is the process of neoplastic invasion of nerves and is an under‐
recognized route of metastatic spread. It is emerging as an important pathologic feature of …

Background In recent years, the significance of the nervous system in the tumor
microenvironment has gained increasing attention. The bidirectional communication …

The College of American Pathologists offers these pro-tocols to assist pathologists in
providing clinically useful and relevant information when reporting results of surgical …

Background Perineural invasion (PNI) may influence the prognosis after resection of
colorectal cancer (CRC); whether this is a definite prognostic factor remains controversial …

BACKGROUND: The authors' purpose was to explore the incidence and prognostic
significance of perineural invasion (PNI) in pT3N0 rectal cancer. METHODS: Pathologic …

Background Colon cancer is a worldwide leading cause of cancer-related mortality, and the
prognosis of colon cancer is still needed to be improved. This study aimed to construct a …

Objectives: Patients with high-risk stage II colon cancer (CC) are recommended to undergo
adjuvant chemotherapy (ACT). However, whether such patients can benefit from ACT …

Objective: To provide a comprehensive characterization of neural invasion (NI) in rectal
adenocarcinoma (RC), to establish a novel NI-severity scoring system, and to assess the …

In locally advanced rectal adenocarcinoma, preoperative radiochemotherapy induces tumor
response. The impact of pathologic tumor response on survival is still debated because of …

The enteric nervous system is an autonomous neuronal circuit that regulates many
processes far beyond the peristalsis in the gastro-intestinal tract. This circuit, consisting of …