Advances of the small molecule drugs regulating fibroblast-like synovial proliferation for rheumatoid arthritis

Y Tong, X Li, Q Deng, J Shi, Y Feng… - Frontiers in Pharmacology, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is a type of chronic autoimmune and inflammatory disease. In the
pathological process of RA, the alteration of fibroblast-like synoviocyte (FLS) and its related …

Role of natural products in alleviation of rheumatoid arthritis—A review

D Sharma, P Chaubey… - Journal of food …, 2021 - Wiley Online Library
Rheumatoid arthritis (RHA) is one of the most prevalent complex, chronic, inflammatory
diseases, manifested by elevated oxidative stress and inflammatory biomarkers. Prolonged …

Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug

S Samarpita, JY Kim, MK Rasool, KS Kim - Arthritis research & therapy, 2020 - Springer
Background Proper blocking of toll-like receptor (TLR) activation during disease progression
has been reported to have inhibitory effect on the pathogenesis of rheumatoid arthritis (RA) …

Deciphering the impact and mechanism of Trikatu, a spices-based formulation on alcoholic liver disease employing network pharmacology analysis and in vivo …

R Sharma, M Jadhav, N Choudhary, A Kumar… - Frontiers in …, 2022 - frontiersin.org
Trikatu Churna (TC) comprising Zingiber officinale rhizome, Piper longum, and Piper nigrum
fruit, is effective in treating liver diseases and has high nutraceutical values. However, the …

Plasma interleukin-38 in patients with rheumatoid arthritis

WD Xu, LC Su, CS He, AF Huang - International immunopharmacology, 2018 - Elsevier
Previous studies have indicated that interleukin-38 (IL-38) is involved in rheumatoid arthritis
(RA). The present study aims to assess plasma levels of IL-38 in RA and discuss the …

Transdermal delivery system of nanostructured lipid carriers loaded with celastrol and indomethacin: optimization, characterization and efficacy evaluation for …

Q Kang, J Liu, Y Zhao, X Liu, XY Liu… - Artificial Cells …, 2018 - Taylor & Francis
Co-encapsulation of drugs provides a convenient means for treating different symptoms of a
disease. Celastrol (Cel) shows potent anti-arthritic activity and Indomethacin (Indo) is …

Data-driven analysis of biomedical literature suggests broad-spectrum benefits of culinary herbs and spices

NK Rakhi, R Tuwani, J Mukherjee, G Bagler - PloS one, 2018 - journals.plos.org
Spices and herbs are key dietary ingredients used across cultures worldwide. Beyond their
use as flavoring and coloring agents, the popularity of these aromatic plant products in …

Anti-inflammatory and Anti-arthritic Activities of Glycosylated Flavonoids from Syzygium jambos in Edematogenic Agent-Induced Paw Edema in Mice

L Apaza Ticona, B Souto Pérez… - Revista Brasileira de …, 2021 - Springer
Two glycosylated flavonoids, the quercetin-3-O-β-d-xylofuranosyl-(1→ 2)-α-l-
rhamnopyranoside and myricetin-3-O-β-d-xylofuranosyl-(1→ 2)-α-l-rhamnopyranoside, were …

NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis

Y Liu, X Yan, H Yu, Y Yao, J Wang, X Li, R Chen… - Molecular …, 2017 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease and the
pathogenesis remains unclear. Previous studies suggested that fibroblast-like synoviocytes …

Tamarixinin A alleviates joint destruction of rheumatoid arthritis by blockade of MAPK and NF-κB activation

Y Zhuang, J Liu, P Ma, J Bai, Y Ding, H Yang… - Frontiers in …, 2017 - frontiersin.org
Background: Tamarixinin A, a natural tannin isolated from Myricaria bracteata, has been
confirmed to have moderate anti-inflammatory effects in vitro and in vivo. However, how it …