Phage therapy in the postantibiotic era

FL Gordillo Altamirano, JJ Barr - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Antibiotic resistance is arguably the biggest current threat to global health. An increasing
number of infections are becoming harder or almost impossible to treat, carrying high …

The human gut microbiome–a potential controller of wellness and disease

ZY Kho, SK Lal - Frontiers in microbiology, 2018 - frontiersin.org
Interest toward the human microbiome, particularly gut microbiome has flourished in recent
decades owing to the rapidly advancing sequence-based screening and humanized …

Resistance development to bacteriophages occurring during bacteriophage therapy

F Oechslin - Viruses, 2018 - mdpi.com
Bacteriophage (phage) therapy, ie, the use of viruses that infect bacteria as antimicrobial
agents, is a promising alternative to conventional antibiotics. Indeed, resistance to antibiotics …

Interactions between bacteriophage, bacteria, and the mammalian immune system

JD Van Belleghem, K Dąbrowska, M Vaneechoutte… - Viruses, 2018 - mdpi.com
The human body is host to large numbers of bacteriophages (phages)–a diverse group of
bacterial viruses that infect bacteria. Phage were previously regarded as bystanders that …

[HTML][HTML] Biotechnological applications of bacteriophages: State of the art

LK Harada, EC Silva, WF Campos, FS Del Fiol… - Microbiological …, 2018 - Elsevier
Bacteriophage particles are the most abundant biological entities on our planet, infecting
specific bacterial hosts in every known environment and being major drivers of bacterial …

Phage therapy: What factors shape phage pharmacokinetics and bioavailability? Systematic and critical review

K Dąbrowska - Medicinal research reviews, 2019 - Wiley Online Library
Bacteriophages are not forgotten viruses anymore: scientists and practitioners seek to
understand phage pharmacokinetics in animals and humans, investigating bacteriophages …

Fecal microbiota transplantation as new therapeutic avenue for human diseases

M Biazzo, G Deidda - Journal of Clinical Medicine, 2022 - mdpi.com
The human body is home to a variety of micro-organisms. Most of these microbial
communities reside in the gut and are referred to as gut microbiota. Over the last decades …

Pharmacologically aware phage therapy: pharmacodynamic and pharmacokinetic obstacles to phage antibacterial action in animal and human bodies

K Dąbrowska, ST Abedon - Microbiology and Molecular Biology …, 2019 - Am Soc Microbiol
The use of viruses infecting bacteria (bacteriophages or phages) to treat bacterial infections
has been ongoing clinically for approximately 100 years. Despite that long history, the …

Encapsulation and delivery of therapeutic phages

B Loh, VS Gondil, P Manohar, FM Khan… - Applied and …, 2021 - Am Soc Microbiol
Delivery of therapeutic compounds to the site of action is crucial. While many chemical
substances such as beta-lactam antibiotics can reach therapeutic levels in most parts …

Pseudomonas predators: understanding and exploiting phage–host interactions

J De Smet, H Hendrix, BG Blasdel… - Nature Reviews …, 2017 - nature.com
Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include
crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant …