Because nuclear factor-κB (NF-κB) is a ubiquitously expressed proinflammatory transcription
factor that regulates the expression of over 500 genes involved in cellular transformation …

Nuclear factor kappa B (NF-κB) transcription factors regulate several important physiological
processes, including inflammation and immune responses, cell growth, apoptosis, and the …

Asthma and chronic obstructive pulmonary disease are inflammatory lung disorders
responsible for significant morbidity and mortality worldwide. While the importance of …

Acting via the glucocorticoid receptor (GR), glucocorticoids exert potent anti-inflammatory
effects partly by repressing inflammatory gene transcription occurring via factors such as NF …

We have previously reported that IL-β-induced miR-146a and miR-146b expression
negatively regulates IL-8 and RANTES release in human alveolar A549 epithelial cells. To …

Since protein kinase C (PKC) isoforms are variously implicated in the activation of NF-κB, we
have investigated the role of PKC in the activation of NF-κB-dependent transcription by the …

Simple Summary The incidence of pancreatic cancer is increasing but there has been little
progress in the diagnosis and survival rates of this lethal cancer for decades. Understanding …

Binding of glucocorticoid to the glucocorticoid receptor (GR/NR3C1) may repress
inflammatory gene transcription via direct, protein synthesis-independent processes …

Nuclear factor kappa B (NF-κ B) is a critical transcription factor for the production of many
inflammatory cytokines. It is activated in the airway epithelium of human asthmatics and in …

Airway mucus secretion is an essential innate immune response for host protection.
However, overproduction and hypersecretion of mucus, mainly composed of MUC5AC, are …