In most cases, sorafenib-resistant HCC cells exhibit significant mesenchymal phenotype and
stemness features. In this context, tumor cells might undergo cell fate transition in response …

Hepatocellular carcinoma (HCC) is a common malignancy and one of the leading causes of
cancer-related death. The biological process of HCC is complex, with multiple factors …

Enhanced glycolysis and accumulation of lactate is a common feature in various types of
cancer. Intracellular lactate drives a recently described type of posttranslational modification …

Involvement of TIGIT in Natural Killer Cell Exhaustion and I... : Hepatology Involvement of
TIGIT in Natural Killer Cell Exhaustion and Immune Escape in Patients and Mouse Model With …

Metabolic reprogramming is critical for the polarization and function of tumor-associated
macrophages (TAM) and hepatocarcinogenesis, but how this reprogramming occurs is …

Lipids represent the essential components of membranes, serve as fuels for high-energy
processes, and play crucial roles in signaling and cellular function. One of the key hallmarks …

Metabolic reprogramming is critically involved in the development and progression of
cancer. In particular, lipid metabolism has been investigated as a source of energy, micro …

With the rapid expansion of the obesity epidemic, nonalcoholic fatty liver disease is now the
most common chronic liver disease, with almost 25% global prevalence. Nonalcoholic fatty …

Metabolic reprogramming for adaptation to the local environment has been recognized as a
hallmark of cancer. Although alterations in fatty acid (FA) metabolism in cancer cells have …

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver with a high worldwide
prevalence and poor prognosis. Researches are urgently needed on its molecular …