A2A adenosine receptor deletion is protective in a mouse model of Tauopathy
C Laurent, S Burnouf, B Ferry, VL Batalha… - Molecular …, 2016 - nature.com
Consumption of caffeine, a non-selective adenosine A 2A receptor (A 2A R) antagonist,
reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both …
reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both …
Ketamine treatment involves medial prefrontal cortex serotonin to induce a rapid antidepressant-like activity in BALB/cJ mice
TH Pham, I Mendez-David, C Defaix, BP Guiard… - …, 2017 - Elsevier
Unlike classic serotonergic antidepressant drugs, ketamine, an NMDA receptor antagonist,
exhibits a rapid and persistent antidepressant (AD) activity, at sub-anaesthetic doses in …
exhibits a rapid and persistent antidepressant (AD) activity, at sub-anaesthetic doses in …
Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus
T Deltheil, BP Guiard, JP Guilloux, L Nicolas… - Pharmacology …, 2008 - Elsevier
In vivo intracerebral microdialysis is an important neurochemical technique that has been
applied extensively in genetic and pharmacological studies aimed at investigating the …
applied extensively in genetic and pharmacological studies aimed at investigating the …
Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive …
G Griebel, P Pichat, S Beeské, T Leroy, N Redon… - Scientific reports, 2015 - nature.com
Monoacylglycerol lipase (MAGL) represents a primary degradation enzyme of the
endogenous cannabinoid (eCB), 2-arachidonoyglycerol (2-AG). This study reports a potent …
endogenous cannabinoid (eCB), 2-arachidonoyglycerol (2-AG). This study reports a potent …
In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction
Background A severe encephalitis that associates with auto-antibodies to the NR1 subunit of
the NMDA receptor (NMDA-R) was recently reported. Patients' antibodies cause a decrease …
the NMDA receptor (NMDA-R) was recently reported. Patients' antibodies cause a decrease …
Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions
M Manto, J Honnorat, CS Hampe… - Frontiers in behavioral …, 2015 - frontiersin.org
Autoantibodies to the smaller isoform of glutamate decarboxylase (GAD) can be found in
patients with type 1 diabetes and a number of neurological disorders, including stiff-person …
patients with type 1 diabetes and a number of neurological disorders, including stiff-person …
Involvement of κ-opioid and endocannabinoid system on Salvinorin A-induced reward
BACKGROUND: The recreational drug, Salvinorin A, derived from the plant of Salvia
divinorum, is a potent and selective κ-opioid receptor agonist. The abuse of selective k …
divinorum, is a potent and selective κ-opioid receptor agonist. The abuse of selective k …
Antidepressant activity: contribution of brain microdialysis in knock-out mice to the understanding of BDNF/5-HT transporter/5-HT autoreceptor interactions
AM Gardier - Frontiers in pharmacology, 2013 - frontiersin.org
Why antidepressants vary in terms of efficacy is currently unclear. Despite the leadership of
selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression, the precise …
selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression, the precise …
Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex
F Loiseau, A Dekeyne, MJ Millan - Psychopharmacology, 2008 - Springer
Rationale 5-HT 6 receptor antagonists improve cognitive processes in rodents. However,
their site (s) of action remains unexplored and their influence upon social memory has been …
their site (s) of action remains unexplored and their influence upon social memory has been …
Dopaminergic neuromodulation of prefrontal cortex activity requires the NMDA receptor coagonist d-serine
G Dallérac, X Li, P Lecouflet… - Proceedings of the …, 2021 - National Acad Sciences
Prefrontal control of cognitive functions critically depends upon glutamatergic transmission
and N-methyl D-aspartate (NMDA) receptors, the activity of which is regulated by dopamine …
and N-methyl D-aspartate (NMDA) receptors, the activity of which is regulated by dopamine …