Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

MYC oncogene is a transcription factor with a wide array of functions affecting cellular
activities such as cell cycle, apoptosis, DNA damage response, and hematopoiesis. Due to …

Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific
metabolic changes remains unclear. Here we show, using the comprehensive measurement …

Soon after the discovery of the Myc gene (c-Myc), it became clear that Myc expression levels
tightly correlate to cell proliferation. The entry in cell cycle of quiescent cells upon Myc …

Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC).
MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also …

Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently
defined by recurrent cytogenetic abnormalities, including rearrangements involving the core …

Germinal centers (GCs) are sites of intense B cell proliferation and are central for T cell–
dependent antibody responses. However, the role of c-Myc, a key cell-cycle regulator, in this …

The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated
protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells …

▪ Abstract The Myc/Max/Mad network comprises a group of transcription factors whose
distinct interactions result in gene-specific transcriptional activation or repression. A great …

Deregulated expression of c-MYC occurs in a broad range of human cancers and is often
associated with poor prognosis, indicating a key role for this oncogene in tumour …