The origins of low-temperature tissue storage research date back to the late 1800s. Over half
a century later, osmotic stress was revealed to be a main contributor to cell death during …

Since the first human hepatocyte transplants (HTx) in 1992, clinical studies have clearly
established proof of principle for this therapy as a treatment for patients with acquired or …

Despite advances in stem cell research, cell transplantation therapy for liver failure is
impeded by a shortage of human primary hepatocytes (HPH), along with current …

Background & Aims Hepatocyte transplantation partially corrects genetic disorders and has
been associated anecdotally with reversal of acute liver failure. Monitoring for graft function …

Orthotopic liver transplantation remains the only curative treatment for many end‐stage liver
diseases, yet the number of patients receiving liver transplants remains limited by the …

Liver disease is prevalent worldwide. When it reaches the end stage, mortality rises to 50%
or more. Although liver transplantation has emerged as the most efficient treatment for end …

The purpose of this review is to educate the reader on the role that cryopreservation has
played and continues to play in the ever-evolving field of assisted reproductive technologies …

There is an ever-growing need of human tissues and organs for transplantation. However,
the availability of such tissues and organs is insufficient by a large margin, which is a huge …

Being an integral part of basic, translational and clinical research, the demand for primary
human hepatocytes (PHH) is continuously growing while the availability of tissue resection …

Introduction: Due to its complex mechanisms and unpredictable occurrence, drug-induced
liver injury (DILI) complicates drug identification and classification. Since species-specific …