The genetics of bipolar disorder

FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

Genetics of bipolar disorder

N Craddock, P Sklar - The Lancet, 2013 - thelancet.com
Studies of families and twins show the importance of genetic factors affecting susceptibility to
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

N Mullins, AJ Forstner, KS O'Connell, B Coombes… - Nature …, 2021 - nature.com
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Genome-wide association study identifies 30 loci associated with bipolar disorder

EA Stahl, G Breen, AJ Forstner, A McQuillin, S Ripke… - Nature …, 2019 - nature.com
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

BJ O'Roak, L Vives, S Girirajan, E Karakoc, N Krumm… - Nature, 2012 - nature.com
It is well established that autism spectrum disorders (ASD) have a strong genetic
component; however, for at least 70% of cases, the underlying genetic cause is unknown …

Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4

Nature genetics, 2011 - nature.com
We conducted a combined genome-wide association study (GWAS) of 7,481 individuals
with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS …

Stress signalling pathways that impair prefrontal cortex structure and function

AFT Arnsten - Nature reviews neuroscience, 2009 - nature.com
The prefrontal cortex (PFC)—the most evolved brain region—subserves our highest-order
cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental …

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

JC Barrett, DG Clayton, P Concannon, B Akolkar… - Nature …, 2009 - nature.com
Abstract Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the
action of multiple genetic and environmental risk factors. We report the findings of a genome …

Circadian rhythm in bipolar disorder: a review of the literature

Y Takaesu - Psychiatry and clinical neurosciences, 2018 - Wiley Online Library
Sleep disturbances and circadian rhythm dysfunction have been widely demonstrated in
patients with bipolar disorder (BD). Irregularity of the sleep–wake rhythm, eveningness …

Genome-wide association study reveals two new risk loci for bipolar disorder

TW Mühleisen, M Leber, TG Schulze… - Nature …, 2014 - nature.com
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants …