The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the
immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling …

Recurrent spontaneous abortion affects approximately 1–2% of women of childbearing, and
describes a condition in which women suffer from three or more continuous spontaneous …

The Signal Transducer and Activator of Transcription (STAT)-5 proteins are required in
immune regulation and homeostasis and play a crucial role in the development and function …

The presence of polyfunctional CD4+ T cells is often associated with favorable antitumor
immunity. We report here that persistent activation of signal transducer and activator of …

The liver is an important immunological organ that controls systemic tolerance. The liver
harbors professional and unconventional antigen-presenting cells that are crucial for …

Preterm birth is the leading cause of mortality in children under the age of five worldwide.
Despite major efforts, we still lack the ability to accurately predict and effectively prevent …

The transcription factors STAT5A and STAT5B have essential roles in survival and
proliferation of hematopoietic cells—which have been considered largely redundant …

Interleukin-2 (IL-2) and Janus kinases (JAKs) regulate transcriptional programs and protein
synthesis to promote the differentiation of effector CD8+ cytotoxic T lymphocytes (CTLs) …

Signal transducer and activator of transcription 3 (STAT3) is a key transcription factor
involved in regulation of immune cell activation and differentiation. Recent discoveries …

Skeletal muscle accounts for the largest proportion of human body mass, on average, and is
a key tissue in complex diseases and mobility. It is composed of several different cell and …