6-modified bicyclic nucleic acid analogs
PP Seth, EE Swayze - US Patent 7,399,845, 2008 - Google Patents
The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric
compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside …
compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside …
Rna interference mediating small rna molecules
T Tuschl, S Elbashir, W Lendeckel, M Wilm… - US Patent App. 10 …, 2004 - Google Patents
Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene
Silencing in many organisms by a process known as RNA interference (RNAi). Using a …
Silencing in many organisms by a process known as RNA interference (RNAi). Using a …
Modified polynucleotides for the production of biologics and proteins associated with human disease
S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49235350&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
RNA interference mediated inhibition of adenosine A1 receptor (ADORA1) gene expression using short interfering RNA
K Fosnaugh, J McSwiggen - US Patent App. 10/224,005, 2003 - Google Patents
Correspondence Address: MCDONNELL BOEHNEN HULBERT &(57) ABSTRACT
BERGHOFF The present invention concerns methods and reagents useful 300 SOUTH …
BERGHOFF The present invention concerns methods and reagents useful 300 SOUTH …
5′-modified bicyclic nucleic acid analogs
PP Seth, EE Swayze, B Bhat - US Patent 7,547,684, 2009 - Google Patents
The present invention provides 5'-modi? ed bicyclic nucleo side analogs and oligomeric
compounds comprising at least one of these nucleoside analogs. In preferred embodiments …
compounds comprising at least one of these nucleoside analogs. In preferred embodiments …
6-modified bicyclic nucleic acid analogs
PP Seth, EE Swayze - US Patent 7,741,457, 2010 - Google Patents
5,023,243 A 6, 1991 Tullis 5,034,506 A 7, 1991 Summerton et al. 5,118,800 A 6, 1992 Smith
et al. The present invention provides 6-modified bicyclic nucleo 5,130,302 A 7/1992 …
et al. The present invention provides 6-modified bicyclic nucleo 5,130,302 A 7/1992 …
Nucleosidic and non-nucleosidic folate conjugates
AP Guzaev, PD Cook, M Manoharan, B Bhat - US Patent 6,335,434, 2002 - Google Patents
4,828,979 A 5/1989 Klevan et a1_ _ __ 435/6 5,416,016 A 5/1995 Low et al..................
435/240.1 4,835,263 A 5/1989 Nguyen et a1_ 536/27 5,416,203 A 5/1995 …
435/240.1 4,835,263 A 5/1989 Nguyen et a1_ 536/27 5,416,203 A 5/1995 …
Compounds and methods for synthesis of bicyclic nucleic acid analogs
B Bhat, J Xia, PP Seth, G Vasquez, MT Migawa… - US Patent …, 2009 - Google Patents
(63) Continuation-in-part of application No. 1 1/627,964, 5.405, 938 A 4/1995 Summerton et
al. filed on Jan. 27, 2007, now Pat. No. 7,399,845. 5,405,939 A 4/1995 Suhadolnik et al.(60) …
al. filed on Jan. 27, 2007, now Pat. No. 7,399,845. 5,405,939 A 4/1995 Suhadolnik et al.(60) …
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid
J McSwiggen, L Beigelman - US Patent 8,202,979, 2012 - Google Patents
2004-09-27 Assigned to SIRNA THERAPEUTICS, INC. reassignment SIRNA
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
THERAPEUTICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …
Interfering RNA molecules
K Giese, J Kaufmann, A Klippel-Giese - US Patent 7,452,987, 2008 - Google Patents
The present invention is related to a ribonucleic acid com prising a double stranded
structure whereby the double Stranded structure comprises a first strand and a second …
structure whereby the double Stranded structure comprises a first strand and a second …