Model systems for regeneration: zebrafish

IJ Marques, E Lupi, N Mercader - Development, 2019 - journals.biologists.com
Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Modeling inflammation in zebrafish for the development of anti-inflammatory drugs

Y Xie, AH Meijer, MJM Schaaf - Frontiers in cell and developmental …, 2021 - frontiersin.org
Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

DB Gurevich, CE Severn, C Twomey… - The EMBO …, 2018 - embopress.org
Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies
of healing. Here, we investigate the cellular interactions between innate immune cells and …

Immunomodulation-accelerated neuronal regeneration following selective rod photoreceptor cell ablation in the zebrafish retina

DT White, S Sengupta, MT Saxena… - Proceedings of the …, 2017 - National Acad Sciences
Müller glia (MG) function as inducible retinal stem cells in zebrafish, completely repairing the
eye after damage. The innate immune system has recently been shown to promote tissue …

[HTML][HTML] Dynamic changes in microglial and macrophage characteristics during degeneration and regeneration of the zebrafish retina

DM Mitchell, AG Lovel, DL Stenkamp - Journal of Neuroinflammation, 2018 - Springer
Background In contrast to mammals, zebrafish have the capacity to regenerate retinal
neurons following a variety of injuries. Two types of glial cells, Müller glia (MG) and …

Peripheral macrophages promote tissue regeneration in zebrafish by fine-tuning the inflammatory response

RA Morales, ML Allende - Frontiers in immunology, 2019 - frontiersin.org
The role of macrophages during regeneration in zebrafish has been well-documented.
Nevertheless, new evidence indicates that zebrafish macrophages are a heterogeneous …

Wilms tumor 1b expression defines a pro-regenerative macrophage subtype and is required for organ regeneration in the zebrafish

A Sanz-Morejon, AB Garcia-Redondo, H Reuter… - Cell reports, 2019 - cell.com
Organ regeneration is preceded by the recruitment of innate immune cells, which play an
active role during repair and regrowth. Here, we studied macrophage subtypes during organ …

Macrophages in the human cochlea: saviors or predators—a study using super-resolution immunohistochemistry

W Liu, M Molnar, C Garnham, H Benav… - Frontiers in …, 2018 - frontiersin.org
The human inner ear, which is segregated by a blood/labyrinth barrier, contains resident
macrophages [CD163, ionized calcium-binding adaptor molecule 1 (IBA1)-, and CD68 …

The detrimental and beneficial functions of macrophages after cochlear injury

Y Zhang, Y Li, X Fu, P Wang, Q Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
Macrophages are the main intrinsic immune cells in the cochlea; they can be activated and
play a complicated role after cochlear injury. Many studies have shown that the number of …

[HTML][HTML] Regeneration of the central nervous system-principles from brain regeneration in adult zebrafish

A Zambusi, J Ninkovic - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Poor recovery of neuronal functions is one of the most common healthcare challenges for
patients with different types of brain injuries and/or neurodegenerative diseases …